Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

Jae Hyek Choi; Li Dek Chou; Teryn R. Roberts; Brendan M. Beely; Daniel S. Wendorff; Mark D. Espinoza; Kyle Sieck; Alexander T. Dixon; David Burmeister; Bryan S. Jordan; Matthew Brenner; Zhongping Chen; Corina Necsoiu; Leopoldo C. Cancio; Andriy I. Batchinsky

doi:10.1016/j.burns.2018.10.014

Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

Jae Hyek Choi^*, Li Dek Chou, Teryn R. Roberts, Brendan M. Beely, Daniel S. Wendorff, Mark D. Espinoza, Kyle Sieck, Alexander T. Dixon, David Burmeister, Bryan S. Jordan, Matthew Brenner, Zhongping Chen, Corina Necsoiu, Leopoldo C. Cancio, Andriy I. Batchinsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11–46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods: 16 female Yorkshire pigs received SII and 40% thermal burns. OCT MT and PaO ₂ -to-FiO ₂ ratio (PFR) measurements were taken at baseline, after injury, and at 24, 48, and 72 h after injury. Results: Injury led to thickening of MT which was sustained in animals that developed ARDS. Significant correlations were found between MT, PFR, peak inspiratory pressure (PIP), and total infused fluid volume. Conclusions: OCT is a useful tool to quantify MT changes in the airway following SII and burns. OCT may be effective as a diagnostic tool in the early stages of SII-induced ARDS and should be tested in humans.

Original language	English
Pages (from-to)	589-597
Number of pages	9
Journal	Burns
Volume	45
Issue number	3
DOIs	https://doi.org/10.1016/j.burns.2018.10.014
State	Published - May 2019
Externally published	Yes

Keywords

Acute respiratory distress syndrome
Bronchoscopy
Burns
Optical coherence tomography
Smoke inhalation injury

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10.1016/j.burns.2018.10.014

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Choi, J. H., Chou, L. D., Roberts, T. R., Beely, B. M., Wendorff, D. S., Espinoza, M. D., Sieck, K., Dixon, A. T., Burmeister, D., Jordan, B. S., Brenner, M., Chen, Z., Necsoiu, C., Cancio, L. C., & Batchinsky, A. I. (2019). Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns. Burns, 45(3), 589-597. https://doi.org/10.1016/j.burns.2018.10.014

@article{e9f565531d5f4c1fb00bbaf2971c556e,

title = "Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns",

abstract = " Background: The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11–46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods: 16 female Yorkshire pigs received SII and 40% thermal burns. OCT MT and PaO 2 -to-FiO 2 ratio (PFR) measurements were taken at baseline, after injury, and at 24, 48, and 72 h after injury. Results: Injury led to thickening of MT which was sustained in animals that developed ARDS. Significant correlations were found between MT, PFR, peak inspiratory pressure (PIP), and total infused fluid volume. Conclusions: OCT is a useful tool to quantify MT changes in the airway following SII and burns. OCT may be effective as a diagnostic tool in the early stages of SII-induced ARDS and should be tested in humans.",

keywords = "Acute respiratory distress syndrome, Bronchoscopy, Burns, Optical coherence tomography, Smoke inhalation injury",

author = "Choi, {Jae Hyek} and Chou, {Li Dek} and Roberts, {Teryn R.} and Beely, {Brendan M.} and Wendorff, {Daniel S.} and Espinoza, {Mark D.} and Kyle Sieck and Dixon, {Alexander T.} and David Burmeister and Jordan, {Bryan S.} and Matthew Brenner and Zhongping Chen and Corina Necsoiu and Cancio, {Leopoldo C.} and Batchinsky, {Andriy I.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd and ISBI",

year = "2019",

month = may,

doi = "10.1016/j.burns.2018.10.014",

language = "English",

volume = "45",

pages = "589--597",

journal = "Burns",

issn = "0305-4179",

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Choi, JH, Chou, LD, Roberts, TR, Beely, BM, Wendorff, DS, Espinoza, MD, Sieck, K, Dixon, AT, Burmeister, D, Jordan, BS, Brenner, M, Chen, Z, Necsoiu, C, Cancio, LC & Batchinsky, AI 2019, 'Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns', Burns, vol. 45, no. 3, pp. 589-597. https://doi.org/10.1016/j.burns.2018.10.014

TY - JOUR

T1 - Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

AU - Choi, Jae Hyek

AU - Chou, Li Dek

AU - Roberts, Teryn R.

AU - Beely, Brendan M.

AU - Wendorff, Daniel S.

AU - Espinoza, Mark D.

AU - Sieck, Kyle

AU - Dixon, Alexander T.

AU - Burmeister, David

AU - Jordan, Bryan S.

AU - Brenner, Matthew

AU - Chen, Zhongping

AU - Necsoiu, Corina

AU - Cancio, Leopoldo C.

AU - Batchinsky, Andriy I.

PY - 2019/5

Y1 - 2019/5

N2 - Background: The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11–46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods: 16 female Yorkshire pigs received SII and 40% thermal burns. OCT MT and PaO 2 -to-FiO 2 ratio (PFR) measurements were taken at baseline, after injury, and at 24, 48, and 72 h after injury. Results: Injury led to thickening of MT which was sustained in animals that developed ARDS. Significant correlations were found between MT, PFR, peak inspiratory pressure (PIP), and total infused fluid volume. Conclusions: OCT is a useful tool to quantify MT changes in the airway following SII and burns. OCT may be effective as a diagnostic tool in the early stages of SII-induced ARDS and should be tested in humans.

AB - Background: The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11–46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods: 16 female Yorkshire pigs received SII and 40% thermal burns. OCT MT and PaO 2 -to-FiO 2 ratio (PFR) measurements were taken at baseline, after injury, and at 24, 48, and 72 h after injury. Results: Injury led to thickening of MT which was sustained in animals that developed ARDS. Significant correlations were found between MT, PFR, peak inspiratory pressure (PIP), and total infused fluid volume. Conclusions: OCT is a useful tool to quantify MT changes in the airway following SII and burns. OCT may be effective as a diagnostic tool in the early stages of SII-induced ARDS and should be tested in humans.

KW - Acute respiratory distress syndrome

KW - Bronchoscopy

KW - Burns

KW - Optical coherence tomography

KW - Smoke inhalation injury

UR - http://www.scopus.com/inward/record.url?scp=85057048642&partnerID=8YFLogxK

U2 - 10.1016/j.burns.2018.10.014

DO - 10.1016/j.burns.2018.10.014

M3 - Article

C2 - 30482414

AN - SCOPUS:85057048642

SN - 0305-4179

VL - 45

SP - 589

EP - 597

JO - Burns

JF - Burns

IS - 3

ER -

Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

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