Pollen food allergy syndrome (PFAS): A review of current available literature

Geoffrey Carlson*, Christopher Coop

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations

Abstract

Objective: Pollen food allergy syndrome (PFAS) is a complex syndrome posing a diagnostic and therapeutic challenge. Our objective was to summarize the available literature regarding its prevalence, pathogenesis, diagnosis, and treatment. Data Sources: A PubMed search was performed to include English language articles with the following search terms: pollen food syndrome, pollen food allergy syndrome, PFAS, oral allergy syndrome, OAS, food anaphylaxis, food components. Study Selections: Human articles discussing PFAS. Results: Varying reports have been made of the prevalence of PFAS, ranging from 4.7% to greater than 20% in children and 13% to 58% in adults. Prevalence varies widely by geographic region. PFAS is typically the results of class II food allergens (e.g. sensitized to anaeroallergen, but reaction occurs due to cross reactivity from a food allergen). Commonly these reactions are limited to the oropharynx due to the lability of the proteins causing the reaction. As multiple families of proteins with varying stability cause PFAS, severe systemic reactions are also possible, as anaphylactic shock has been documented in up to 1.7% of reactions. Conclusion: Pollen food allergy syndrome therefore cannot be dismissed as a benign food allergy, but it needs to be approached individually based on known risk factors.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalAnnals of Allergy, Asthma and Immunology
Volume123
Issue number4
DOIs
StatePublished - Oct 2019
Externally publishedYes

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