Polycyclic aromatic hydrocarbons and polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter samples of human serum as exposure indicators

Xiaoyan Xia, Alesia Carroll-Haddad, Nicole Brown, Mark J. Utell, Timothy M. Mallon, Philip K. Hopke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objective: The objectives were: 1) measure polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in 100μL of human serum and 2) assess PAH and PCDD/PCDF as markers of burn pit exposures during military deployments. Methods: PAHs and PCDDs/PCDFs were analyzed in 100μL serum samples collected pre- and post-deployment from 200 persons deployed to Iraq or Afghanistan (CASE); 200 persons not deployed (CONTROL) with gas chromatography/mass spectrometry. Results: Naphthalene was found in ∼83% of the samples and was statistically different between post-deployment CASE personnel and pre-deployment. 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin, Octachlorodibenzo-p-dioxin, 1,2,3,7,8,9-Hexachlorodibenzofuran, and 1,2,3,4,6,7,8-Heptachlorodibenzofuran were found in ∼38% of samples. Concentrations were significantly different between CASE and CONTROL and between pre- and post-deployment samples. Conclusions: PAH and PCDD/PCDF in serum can serve as exposure markers and measurements in small volumes is feasible for quantifying exposure to burn pits.

Original languageEnglish
Pages (from-to)S72-S79
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number8S
DOIs
StatePublished - 1 Aug 2016
Externally publishedYes

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