Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms

Linda M. Bierer; Peter J. Knott; James M. Schmeidler; Deborah B. Marin; Theresa M. Ryan; Vahram Haroutunian; Dushyant P. Purohit; Daniel P. Perl; Richard C. Mohs; Kenneth L. Davis

doi:10.1016/0165-1781(93)90062-L

Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms

Linda M. Bierer^*, Peter J. Knott, James M. Schmeidler, Deborah B. Marin, Theresa M. Ryan, Vahram Haroutunian, Dushyant P. Purohit, Daniel P. Perl, Richard C. Mohs, Kenneth L. Davis

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Psychiatry Research
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(93)90062-L
State	Published - Dec 1993

Keywords

agitation
cognitive impairment
Dementia
depression
dihydroxyphenylacetic acid
homovanillic acid
neuropathology
psychosis
temporal cortex

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10.1016/0165-1781(93)90062-L

Cite this

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title = "Post-mortem examination of dopaminergic parameters in Alzheimer's disease: Relationship to noncognitive symptoms",

abstract = "Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.",

keywords = "agitation, cognitive impairment, Dementia, depression, dihydroxyphenylacetic acid, homovanillic acid, neuropathology, psychosis, temporal cortex",

author = "Bierer, {Linda M.} and Knott, {Peter J.} and Schmeidler, {James M.} and Marin, {Deborah B.} and Ryan, {Theresa M.} and Vahram Haroutunian and Purohit, {Dushyant P.} and Perl, {Daniel P.} and Mohs, {Richard C.} and Davis, {Kenneth L.}",

year = "1993",

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doi = "10.1016/0165-1781(93)90062-L",

language = "English",

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T1 - Post-mortem examination of dopaminergic parameters in Alzheimer's disease

T2 - Relationship to noncognitive symptoms

AU - Bierer, Linda M.

AU - Knott, Peter J.

AU - Schmeidler, James M.

AU - Marin, Deborah B.

AU - Ryan, Theresa M.

AU - Haroutunian, Vahram

AU - Purohit, Dushyant P.

AU - Perl, Daniel P.

AU - Mohs, Richard C.

AU - Davis, Kenneth L.

PY - 1993/12

Y1 - 1993/12

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AB - Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis-symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

KW - agitation

KW - cognitive impairment

KW - Dementia

KW - depression

KW - dihydroxyphenylacetic acid

KW - homovanillic acid

KW - neuropathology

KW - psychosis

KW - temporal cortex

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