Postovariectomy weight gain in female rats is reversed by estrogen receptor alpha agonist, propylpyrazoletriol

Iga N Wegorzewska; Katy Walters; Michael J Weiser; Danette F Cruthirds; Emily Ewell; Darwin O Larco; Robert J Handa; T John Wu

doi:10.1016/j.ajog.2007.11.054

Postovariectomy weight gain in female rats is reversed by estrogen receptor alpha agonist, propylpyrazoletriol

Iga N Wegorzewska, Katy Walters, Michael J Weiser, Danette F Cruthirds, Emily Ewell, Darwin O Larco, Robert J Handa, T John Wu

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERalpha and ERbeta, on body weight regulation using a rat model of weight gain subsequent to menopause.

STUDY DESIGN: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17beta (E2), propylpyrazoletriol (PPT; ERalpha agonist) and diarylpropionitrile (DPN; ERbeta agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized.

RESULTS: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment.

CONCLUSION: These results suggest that the activation of ERalpha is important in regulating body weight.

Original language	English
Pages (from-to)	67.e1-5
Journal	American Journal of Obstetrics and Gynecology
Volume	199
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2007.11.054
State	Published - Jul 2008

Keywords

Animals
Disease Models, Animal
Estradiol/pharmacology
Estrogen Receptor alpha/agonists
Estrogen Receptor beta/agonists
Estrogens/pharmacology
Female
Nitriles/pharmacology
Ovariectomy/adverse effects
Phenols
Propionates/pharmacology
Pyrazoles/pharmacology
Rats
Rats, Long-Evans
Receptors, Estrogen/agonists
Weight Gain/drug effects

Access to Document

10.1016/j.ajog.2007.11.054

Cite this

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title = "Postovariectomy weight gain in female rats is reversed by estrogen receptor alpha agonist, propylpyrazoletriol",

abstract = "OBJECTIVE: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERalpha and ERbeta, on body weight regulation using a rat model of weight gain subsequent to menopause.STUDY DESIGN: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17beta (E2), propylpyrazoletriol (PPT; ERalpha agonist) and diarylpropionitrile (DPN; ERbeta agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized.RESULTS: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment.CONCLUSION: These results suggest that the activation of ERalpha is important in regulating body weight.",

keywords = "Animals, Disease Models, Animal, Estradiol/pharmacology, Estrogen Receptor alpha/agonists, Estrogen Receptor beta/agonists, Estrogens/pharmacology, Female, Nitriles/pharmacology, Ovariectomy/adverse effects, Phenols, Propionates/pharmacology, Pyrazoles/pharmacology, Rats, Rats, Long-Evans, Receptors, Estrogen/agonists, Weight Gain/drug effects",

author = "Wegorzewska, {Iga N} and Katy Walters and Weiser, {Michael J} and Cruthirds, {Danette F} and Emily Ewell and Larco, {Darwin O} and Handa, {Robert J} and Wu, {T John}",

year = "2008",

month = jul,

doi = "10.1016/j.ajog.2007.11.054",

language = "English",

volume = "199",

pages = "67.e1--5",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",

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AU - Wegorzewska, Iga N

AU - Walters, Katy

AU - Weiser, Michael J

AU - Cruthirds, Danette F

AU - Ewell, Emily

AU - Larco, Darwin O

AU - Handa, Robert J

AU - Wu, T John

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N2 - OBJECTIVE: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERalpha and ERbeta, on body weight regulation using a rat model of weight gain subsequent to menopause.STUDY DESIGN: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17beta (E2), propylpyrazoletriol (PPT; ERalpha agonist) and diarylpropionitrile (DPN; ERbeta agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized.RESULTS: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment.CONCLUSION: These results suggest that the activation of ERalpha is important in regulating body weight.

AB - OBJECTIVE: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERalpha and ERbeta, on body weight regulation using a rat model of weight gain subsequent to menopause.STUDY DESIGN: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17beta (E2), propylpyrazoletriol (PPT; ERalpha agonist) and diarylpropionitrile (DPN; ERbeta agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized.RESULTS: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment.CONCLUSION: These results suggest that the activation of ERalpha is important in regulating body weight.

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KW - Ovariectomy/adverse effects

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