@article{cca71baf613a4b7681c286e51ac2a0de,
title = "Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine",
abstract = "In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.",
keywords = "HBOC-201, Hemorrhage, Pre-hospital trauma care, RFVIIa, Resuscitation",
author = "Ashraful Haque and Fran{\c c}oise Arnaud and Kohsuke Teranishi and Tomoaki Okada and Bobby Kim and Moon-Massat, {Paula F.} and Charles Auker and Richard McCarron and Daniel Freilich and Scultetus, {Anke H.}",
note = "Funding Information: This work was supported by BUMED Core Capability Funding Work Unit Number 602236N.4426.W26.A0241. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. The authors thank Noemy Carballo, Mike Hammett, and Sarah Michaud from the Naval Medical Research Center for their technical assistance, and Gerald McGwin, Ph.D., University of Alabama, for statistical analysis. Address correspondence to Ashraful Haque, MD, Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA. E-mail: ashraful.haque@ med.navy.mil",
year = "2012",
month = feb,
doi = "10.3109/10731199.2011.585615",
language = "English",
volume = "40",
pages = "44--55",
journal = "Artificial Cells, Blood Substitutes, and Biotechnology",
issn = "1073-1199",
number = "1-2",
}