Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

Ashraful Haque; Françoise Arnaud; Kohsuke Teranishi; Tomoaki Okada; Bobby Kim; Paula F. Moon-Massat; Charles Auker; Richard McCarron; Daniel Freilich; Anke H. Scultetus

doi:10.3109/10731199.2011.585615

Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

Ashraful Haque^*
, Françoise Arnaud
, Kohsuke Teranishi
, Tomoaki Okada
, Bobby Kim
, Paula F. Moon-Massat
, Charles Auker
, Richard McCarron
, Daniel Freilich
, Anke H. Scultetus

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.

Original language	English
Pages (from-to)	44-55
Number of pages	12
Journal	Artificial Cells, Blood Substitutes, and Biotechnology
Volume	40
Issue number	1-2
DOIs	https://doi.org/10.3109/10731199.2011.585615
State	Published - Feb 2012

Keywords

HBOC-201
Hemorrhage
Pre-hospital trauma care
RFVIIa
Resuscitation

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10.3109/10731199.2011.585615

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Haque, A., Arnaud, F., Teranishi, K., Okada, T., Kim, B., Moon-Massat, P. F., Auker, C., McCarron, R., Freilich, D., & Scultetus, A. H. (2012). Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine. Artificial Cells, Blood Substitutes, and Biotechnology, 40(1-2), 44-55. https://doi.org/10.3109/10731199.2011.585615

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title = "Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine",

abstract = "In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.",

keywords = "HBOC-201, Hemorrhage, Pre-hospital trauma care, RFVIIa, Resuscitation",

author = "Ashraful Haque and Fran{\c c}oise Arnaud and Kohsuke Teranishi and Tomoaki Okada and Bobby Kim and Moon-Massat, \{Paula F.\} and Charles Auker and Richard McCarron and Daniel Freilich and Scultetus, \{Anke H.\}",

note = "Funding Information: This work was supported by BUMED Core Capability Funding Work Unit Number 602236N.4426.W26.A0241. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. The authors thank Noemy Carballo, Mike Hammett, and Sarah Michaud from the Naval Medical Research Center for their technical assistance, and Gerald McGwin, Ph.D., University of Alabama, for statistical analysis. Address correspondence to Ashraful Haque, MD, Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA. E-mail: ashraful.haque@ med.navy.mil",

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Haque, A, Arnaud, F, Teranishi, K, Okada, T, Kim, B, Moon-Massat, PF, Auker, C, McCarron, R, Freilich, D & Scultetus, AH 2012, 'Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine', Artificial Cells, Blood Substitutes, and Biotechnology, vol. 40, no. 1-2, pp. 44-55. https://doi.org/10.3109/10731199.2011.585615

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T1 - Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

AU - Haque, Ashraful

AU - Arnaud, Françoise

AU - Teranishi, Kohsuke

AU - Okada, Tomoaki

AU - Kim, Bobby

AU - Moon-Massat, Paula F.

AU - Auker, Charles

AU - McCarron, Richard

AU - Freilich, Daniel

AU - Scultetus, Anke H.

N1 - Funding Information: This work was supported by BUMED Core Capability Funding Work Unit Number 602236N.4426.W26.A0241. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. The authors thank Noemy Carballo, Mike Hammett, and Sarah Michaud from the Naval Medical Research Center for their technical assistance, and Gerald McGwin, Ph.D., University of Alabama, for statistical analysis. Address correspondence to Ashraful Haque, MD, Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA. E-mail: ashraful.haque@ med.navy.mil

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N2 - In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.

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KW - HBOC-201

KW - Hemorrhage

KW - Pre-hospital trauma care

KW - RFVIIa

KW - Resuscitation

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JO - Artificial Cells, Blood Substitutes, and Biotechnology

JF - Artificial Cells, Blood Substitutes, and Biotechnology

IS - 1-2

ER -

Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine

Abstract

Keywords

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