Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja Cernak; Donald G. Stein; Gregory A. Elder; Stephn Ahlers; Kenneth Curley; Ralph G. DePalma; John Duda; Milos Ikonomovic; Grant L. Iverson; Firas Kobeissy; Vassilis E. Koliatsos; Michael J. Leggieri; Anthony M. Pacifico; Douglas H. Smith; Raymond Swanson; Floyd J. Thompson; Frank C. Tortella

doi:10.1080/02699052.2016.1274779

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja Cernak^*, Donald G. Stein, Gregory A. Elder, Stephn Ahlers, Kenneth Curley, Ralph G. DePalma, John Duda, Milos Ikonomovic, Grant L. Iverson, Firas Kobeissy, Vassilis E. Koliatsos, Michael J. Leggieri, Anthony M. Pacifico, Douglas H. Smith, Raymond Swanson, Floyd J. Thompson, Frank C. Tortella

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

Original language	English
Pages (from-to)	1168-1176
Number of pages	9
Journal	Brain Injury
Volume	31
Issue number	9
DOIs	https://doi.org/10.1080/02699052.2016.1274779
State	Published - 29 Jul 2017
Externally published	Yes

Keywords

United States Department of Veterans Affairs
blast-induced neurotrauma
conference
experimental models
preclinical research
traumatic brain injury

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10.1080/02699052.2016.1274779

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Cernak, I., Stein, D. G., Elder, G. A., Ahlers, S., Curley, K., DePalma, R. G., Duda, J., Ikonomovic, M., Iverson, G. L., Kobeissy, F., Koliatsos, V. E., Leggieri, M. J., Pacifico, A. M., Smith, D. H., Swanson, R., Thompson, F. J., & Tortella, F. C. (2017). Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions. Brain Injury, 31(9), 1168-1176. https://doi.org/10.1080/02699052.2016.1274779

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abstract = "As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.",

keywords = "United States Department of Veterans Affairs, blast-induced neurotrauma, conference, experimental models, preclinical research, traumatic brain injury",

author = "Ibolja Cernak and Stein, {Donald G.} and Elder, {Gregory A.} and Stephn Ahlers and Kenneth Curley and DePalma, {Ralph G.} and John Duda and Milos Ikonomovic and Iverson, {Grant L.} and Firas Kobeissy and Koliatsos, {Vassilis E.} and Leggieri, {Michael J.} and Pacifico, {Anthony M.} and Smith, {Douglas H.} and Raymond Swanson and Thompson, {Floyd J.} and Tortella, {Frank C.}",

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Cernak, I, Stein, DG, Elder, GA, Ahlers, S, Curley, K, DePalma, RG, Duda, J, Ikonomovic, M, Iverson, GL, Kobeissy, F, Koliatsos, VE, Leggieri, MJ, Pacifico, AM, Smith, DH, Swanson, R, Thompson, FJ & Tortella, FC 2017, 'Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions', Brain Injury, vol. 31, no. 9, pp. 1168-1176. https://doi.org/10.1080/02699052.2016.1274779

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AU - Cernak, Ibolja

AU - Stein, Donald G.

AU - Elder, Gregory A.

AU - Ahlers, Stephn

AU - Curley, Kenneth

AU - DePalma, Ralph G.

AU - Duda, John

AU - Ikonomovic, Milos

AU - Iverson, Grant L.

AU - Kobeissy, Firas

AU - Koliatsos, Vassilis E.

AU - Leggieri, Michael J.

AU - Pacifico, Anthony M.

AU - Smith, Douglas H.

AU - Swanson, Raymond

AU - Thompson, Floyd J.

AU - Tortella, Frank C.

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KW - United States Department of Veterans Affairs

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Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Abstract

Keywords

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