TY - JOUR
T1 - Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil
AU - Bedocs, Peter
AU - Evers, David L.
AU - Buckenmaier, Chester C.
N1 - Publisher Copyright:
© 2018 International Anesthesia Research Society.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.
AB - Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.
UR - http://www.scopus.com/inward/record.url?scp=85060932816&partnerID=8YFLogxK
U2 - 10.1213/ANE.0000000000003772
DO - 10.1213/ANE.0000000000003772
M3 - Article
C2 - 30286006
AN - SCOPUS:85060932816
SN - 0003-2999
VL - 129
SP - E13-E15
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 1
ER -