Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil

Peter Bedocs; David L. Evers; Chester C. Buckenmaier

doi:10.1213/ANE.0000000000003772

Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil

Peter Bedocs^*
, David L. Evers
, Chester C. Buckenmaier

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.

Original language	English
Pages (from-to)	E13-E15
Journal	Anesthesia and Analgesia
Volume	129
Issue number	1
DOIs	https://doi.org/10.1213/ANE.0000000000003772
State	Published - 1 Jul 2019

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title = "Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil",

abstract = "Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.",

author = "Peter Bedocs and Evers, \{David L.\} and Buckenmaier, \{Chester C.\}",

note = "Publisher Copyright: {\textcopyright} 2018 International Anesthesia Research Society.",

year = "2019",

month = jul,

day = "1",

doi = "10.1213/ANE.0000000000003772",

language = "English",

volume = "129",

pages = "E13--E15",

journal = "Anesthesia and Analgesia",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil

AU - Bedocs, Peter

AU - Evers, David L.

AU - Buckenmaier, Chester C.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.

AB - Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.

UR - https://www.scopus.com/pages/publications/85060932816

U2 - 10.1213/ANE.0000000000003772

DO - 10.1213/ANE.0000000000003772

M3 - Article

C2 - 30286006

AN - SCOPUS:85060932816

SN - 0003-2999

VL - 129

SP - E13-E15

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

IS - 1

ER -

Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil

Abstract

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