Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination

David A. Lindholm*, Raymond D. Fisher, Jay R. Montgomery, Whitni Davidson, Patricia A. Yu, Yon C. Yu, Jillybeth Burgado, Kimberly Wilkins, Brett W. Petersen, Jason F. Okulicz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.

Original languageEnglish
Pages (from-to)2205-2207
Number of pages3
JournalClinical Infectious Diseases
Volume69
Issue number12
DOIs
StatePublished - 27 Nov 2019
Externally publishedYes

Keywords

  • ST-246
  • leukemia
  • smallpox vaccine
  • tecovirimat
  • vaccinia

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