Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination

David A. Lindholm; Raymond D. Fisher; Jay R. Montgomery; Whitni Davidson; Patricia A. Yu; Yon C. Yu; Jillybeth Burgado; Kimberly Wilkins; Brett W. Petersen; Jason F. Okulicz

doi:10.1093/cid/ciz286

Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination

David A. Lindholm^*, Raymond D. Fisher, Jay R. Montgomery, Whitni Davidson, Patricia A. Yu, Yon C. Yu, Jillybeth Burgado, Kimberly Wilkins, Brett W. Petersen, Jason F. Okulicz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.

Original language	English
Pages (from-to)	2205-2207
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	69
Issue number	12
DOIs	https://doi.org/10.1093/cid/ciz286
State	Published - 27 Nov 2019
Externally published	Yes

Keywords

ST-246
leukemia
smallpox vaccine
tecovirimat
vaccinia

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10.1093/cid/ciz286

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title = "Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination",

abstract = "Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.",

keywords = "ST-246, leukemia, smallpox vaccine, tecovirimat, vaccinia",

author = "Lindholm, \{David A.\} and Fisher, \{Raymond D.\} and Montgomery, \{Jay R.\} and Whitni Davidson and Yu, \{Patricia A.\} and Yu, \{Yon C.\} and Jillybeth Burgado and Kimberly Wilkins and Petersen, \{Brett W.\} and Okulicz, \{Jason F.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

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doi = "10.1093/cid/ciz286",

language = "English",

volume = "69",

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journal = "Clinical Infectious Diseases",

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T1 - Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination

AU - Lindholm, David A.

AU - Fisher, Raymond D.

AU - Montgomery, Jay R.

AU - Davidson, Whitni

AU - Yu, Patricia A.

AU - Yu, Yon C.

AU - Burgado, Jillybeth

AU - Wilkins, Kimberly

AU - Petersen, Brett W.

AU - Okulicz, Jason F.

PY - 2019/11/27

Y1 - 2019/11/27

N2 - Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.

AB - Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.

KW - ST-246

KW - leukemia

KW - smallpox vaccine

KW - tecovirimat

KW - vaccinia

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U2 - 10.1093/cid/ciz286

DO - 10.1093/cid/ciz286

M3 - Article

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SN - 1058-4838

VL - 69

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Preemptive Tecovirimat Use in an Active Duty Service Member Who Presented with Acute Myeloid Leukemia after Smallpox Vaccination

Abstract

Keywords

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