Pregnancy galectinology: Insights into a complex network of glycan binding proteins

Sandra M. Blois; Gabriela Dveksler; Gerardo R. Vasta; Nancy Freitag; Véronique Blanchard; Gabriela Barrientos

doi:10.3389/fimmu.2019.01166

Pregnancy galectinology: Insights into a complex network of glycan binding proteins

Sandra M. Blois^*
, Gabriela Dveksler
, Gerardo R. Vasta
, Nancy Freitag
, Véronique Blanchard
, Gabriela Barrientos

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

Original language	English
Article number	1166
Journal	Frontiers in Immunology
Volume	10
Issue number	MAY
DOIs	https://doi.org/10.3389/fimmu.2019.01166
State	Published - 2019

Keywords

Galectins
Glycans
Placentation
Preeclampsia
Pregnancy

Access to Document

10.3389/fimmu.2019.01166

Cite this

@article{987a4c9acb244a54aec8fef12c9e332d,

title = "Pregnancy galectinology: Insights into a complex network of glycan binding proteins",

abstract = "Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.",

keywords = "Galectins, Glycans, Placentation, Preeclampsia, Pregnancy",

author = "Blois, \{Sandra M.\} and Gabriela Dveksler and Vasta, \{Gerardo R.\} and Nancy Freitag and V{\'e}ronique Blanchard and Gabriela Barrientos",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 Blois, Dveksler, Vasta, Freitag, Blanchard and Barrientos.",

year = "2019",

doi = "10.3389/fimmu.2019.01166",

language = "English",

volume = "10",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

number = "MAY",

}

TY - JOUR

T1 - Pregnancy galectinology

T2 - Insights into a complex network of glycan binding proteins

AU - Blois, Sandra M.

AU - Dveksler, Gabriela

AU - Vasta, Gerardo R.

AU - Freitag, Nancy

AU - Blanchard, Véronique

AU - Barrientos, Gabriela

PY - 2019

Y1 - 2019

N2 - Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

AB - Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

KW - Galectins

KW - Glycans

KW - Placentation

KW - Preeclampsia

KW - Pregnancy

UR - https://www.scopus.com/pages/publications/85068546839

U2 - 10.3389/fimmu.2019.01166

DO - 10.3389/fimmu.2019.01166

M3 - Review article

C2 - 31231368

AN - SCOPUS:85068546839

SN - 1664-3224

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - MAY

M1 - 1166

ER -

Pregnancy galectinology: Insights into a complex network of glycan binding proteins

Abstract

Keywords

Access to Document

Fingerprint

Cite this