TY - JOUR
T1 - Pregnancy outcome of day 3 versus day 5 embryo transfer
T2 - A retrospective analysis
AU - Alfaraj, Samaher
AU - Alzaher, Fatima
AU - Alshwaiaer, Sahar
AU - Ahmed, Anwar
N1 - Funding Information:
This study was approved by the Research and Ethics Committee at the College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Informed consent was obtained from all participants who agreed to share the outcomes of their cycles for research purposes.
Funding Information:
1Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Unit, King Abdul-Aziz Medical City, Riyadh, Saudi Arabia 2Department of Obstetrics and Gynecology, Ministry of Health, Dammam, Saudi Arabia 3Assistant Professor of Biostatistics, Department of Epidemiology and Biostatistics College of Public Health and Health Informatics King Saud Bin Abdulaziz University for Health Sciences National Guard Health Affairs Riyadh, KSA
Publisher Copyright:
© 2017 by the Asian Pacific Journal of Reproduction.
PY - 2017/3
Y1 - 2017/3
N2 - Objective: To compare the pregnancy rate between day 3 and day 5 transfer regardless grades of embryos and number of transferred embryo. Methods: Retrospective cohort, a total of seven hundred and four patients met our inclusion criteria, with 411 had day 3 embryo transfer and 293 had day 5 embryo transfer. The patients who were older than 40 years old were excluded. Embryo transfer was carried out in all patients in both transfer groups. Results: Both clinical pregnancy rate and implantation rate did not show any statistically significant difference between the day 3 and day five transfer groups. These were 44% vs. 45% with P=0.82 and 19% vs. 19% with P=0.99 respectively. An increase of miscarriage rate with day 5 embryo transferred compare with day 3 (12.0% vs. 4.4%, P=0.01), but no significant difference was found about biochemical pregnancy rate (P=0.52). Conclusions: Transferring embryo at day 5 may not provide any additional benefit over day 3 transfers to patients. In addition, it increases the risk of miscarriage. Further studies of this issue needed for confirming our findings.
AB - Objective: To compare the pregnancy rate between day 3 and day 5 transfer regardless grades of embryos and number of transferred embryo. Methods: Retrospective cohort, a total of seven hundred and four patients met our inclusion criteria, with 411 had day 3 embryo transfer and 293 had day 5 embryo transfer. The patients who were older than 40 years old were excluded. Embryo transfer was carried out in all patients in both transfer groups. Results: Both clinical pregnancy rate and implantation rate did not show any statistically significant difference between the day 3 and day five transfer groups. These were 44% vs. 45% with P=0.82 and 19% vs. 19% with P=0.99 respectively. An increase of miscarriage rate with day 5 embryo transferred compare with day 3 (12.0% vs. 4.4%, P=0.01), but no significant difference was found about biochemical pregnancy rate (P=0.52). Conclusions: Transferring embryo at day 5 may not provide any additional benefit over day 3 transfers to patients. In addition, it increases the risk of miscarriage. Further studies of this issue needed for confirming our findings.
KW - Blastocyst
KW - Early cleavage stage
KW - Embryo transfer
KW - Pregnancy outcomes
KW - Sequential culture media
UR - http://www.scopus.com/inward/record.url?scp=85037034445&partnerID=8YFLogxK
U2 - 10.12980/apjr.6.20170208
DO - 10.12980/apjr.6.20170208
M3 - Article
AN - SCOPUS:85037034445
SN - 2305-0500
VL - 6
SP - 89
EP - 92
JO - Asian Pacific Journal of Reproduction
JF - Asian Pacific Journal of Reproduction
IS - 2
ER -