Prenatal exposure to nicotine: Effects on prepulse inhibition and central nicotinic receptors

E. Jon Popke; Yousef Tizabi; Matthew A. Rahman; Stephanie M. Nespor; Neil E. Grunberg

doi:10.1016/S0091-3057(97)98985-1

Prenatal exposure to nicotine: Effects on prepulse inhibition and central nicotinic receptors

E. Jon Popke, Yousef Tizabi, Matthew A. Rahman, Stephanie M. Nespor, Neil E. Grunberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The present experiment examined effects of prenatal nicotine exposure (6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (PPI) and on the density of nicotinic acetylcholine receptors (nAchRs) in the brains of 5-week-old Sprague-Dawley rats. A total of 117 male and 103 female offspring were used. Prenatal nicotine reduced subsequent percent PPI to a 98 dB stimulus in female but not in male offspring. There was an inverse correlation between the percent of PPI and nAchR density in the cortex of male rats and the striatum of female rats.

Original language	English
Pages (from-to)	843-849
Number of pages	7
Journal	Pharmacology, Biochemistry and Behavior
Volume	58
Issue number	4
DOIs	https://doi.org/10.1016/S0091-3057(97)98985-1
State	Published - Dec 1997
Externally published	Yes

Keywords

Nicotinic receptors
Prenatal nicotine
Prepulse inhibition
Sensory gating
Sex differences

Access to Document

10.1016/S0091-3057(97)98985-1

Cite this

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title = "Prenatal exposure to nicotine: Effects on prepulse inhibition and central nicotinic receptors",

abstract = "The present experiment examined effects of prenatal nicotine exposure (6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (PPI) and on the density of nicotinic acetylcholine receptors (nAchRs) in the brains of 5-week-old Sprague-Dawley rats. A total of 117 male and 103 female offspring were used. Prenatal nicotine reduced subsequent percent PPI to a 98 dB stimulus in female but not in male offspring. There was an inverse correlation between the percent of PPI and nAchR density in the cortex of male rats and the striatum of female rats.",

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T2 - Effects on prepulse inhibition and central nicotinic receptors

AU - Popke, E. Jon

AU - Tizabi, Yousef

AU - Rahman, Matthew A.

AU - Nespor, Stephanie M.

AU - Grunberg, Neil E.

PY - 1997/12

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KW - Sensory gating

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