TY - JOUR
T1 - Prevalence and factors associated with anogenital warts among sexual and gender minorities attending a trusted community health center in Lagos, Nigeria
AU - TRUST/RV368 Study Group
AU - Adebajo, Sylvia B.
AU - Nowak, Rebecca G.
AU - Adebiyi, Ruxton
AU - Shoyemi, Elizabeth
AU - Ekeh, Charles
AU - Ramadhani, Habib O.
AU - Gaydos, Charlotte A.
AU - Ake, Julie A.
AU - Baral, Stefan D.
AU - Charurat, Manhattan E.
AU - Crowell, Trevor A.
AU - Charurat, Manhattan
AU - Ake, Julie
AU - Adebajo, Sylvia
AU - Baral, Stefan
AU - Billings, Erik
AU - Crowell, Trevor
AU - Eluwa, George
AU - Gaydos, Charlotte
AU - Kokogho, Afoke
AU - Liu, Hongjie
AU - Malia, Jennifer
AU - Makanjuola, Olumide
AU - Michael, Nelson
AU - Ndembi, Nicaise
AU - Njab, Jean
AU - Nowak, Rebecca
AU - Olawore, Oluwasolape
AU - Parker, Zahra
AU - Peel, Sheila
AU - Ramadhani, Habib
AU - Robb, Merlin
AU - Rodriguez-Hart, Cristina
AU - Sanders-Buell, Eric
AU - Tovanabutra, Sodsai
N1 - Publisher Copyright:
© This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the CreativeCommons CC0 public domain dedication..
PY - 2022/11
Y1 - 2022/11
N2 - Anogenital warts caused by human papillomavirus are common in sexual and gender minorities (SGM). The prevalence of, and factors associated with warts were described for SGM with a high burden of HIV in Nigeria. Individuals who reported anal sex with men were enrolled in the TRUST/RV368 cohort. Participants completed an interviewer-led survey, provided biological samples, and had a physical examination. Specific to the Lagos site, clinic staff offered standardized warts treatment services. RDS-weighted multivariable logistic regression was used to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for factors potentially associated with anogenital warts. Of 672 enrolled SGM, 478 (71%) engaged in warts services and had complete data. The median age (interquartile range) was 22 (20-26) years, 272 (52%) initiated sex before age 18, and 347 (79%) were cisgender men. Multiple male sexual partners in the previous year were reported by 448 (90%) of the participants, and 342 (66%) were living with HIV. Warts were diagnosed in 252 (54%), including anal warts in 234 (43%) and penile warts in 44 (8%); 26 (5%) had both anal and penile warts. Factors independently associated with warts included HIV (AOR:2.97; CI:1.44-6.14), engaging in receptive anal sex (AOR:3.49; CI:1.25-9.75), having multiple male sexual partners (AOR:7.26; CI:2.11-24.87), age at sexual debut (AOR:0.53; CI:0.28- 0.98), and non-binary gender identity (AOR:0.20; CI:0.05-0.71). Warts were common among SGM in Nigeria, particularly those living with HIV. Administration of HPV vaccination before sexual debut or as a catch-up vaccination may prevent HPV-associated complications.
AB - Anogenital warts caused by human papillomavirus are common in sexual and gender minorities (SGM). The prevalence of, and factors associated with warts were described for SGM with a high burden of HIV in Nigeria. Individuals who reported anal sex with men were enrolled in the TRUST/RV368 cohort. Participants completed an interviewer-led survey, provided biological samples, and had a physical examination. Specific to the Lagos site, clinic staff offered standardized warts treatment services. RDS-weighted multivariable logistic regression was used to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for factors potentially associated with anogenital warts. Of 672 enrolled SGM, 478 (71%) engaged in warts services and had complete data. The median age (interquartile range) was 22 (20-26) years, 272 (52%) initiated sex before age 18, and 347 (79%) were cisgender men. Multiple male sexual partners in the previous year were reported by 448 (90%) of the participants, and 342 (66%) were living with HIV. Warts were diagnosed in 252 (54%), including anal warts in 234 (43%) and penile warts in 44 (8%); 26 (5%) had both anal and penile warts. Factors independently associated with warts included HIV (AOR:2.97; CI:1.44-6.14), engaging in receptive anal sex (AOR:3.49; CI:1.25-9.75), having multiple male sexual partners (AOR:7.26; CI:2.11-24.87), age at sexual debut (AOR:0.53; CI:0.28- 0.98), and non-binary gender identity (AOR:0.20; CI:0.05-0.71). Warts were common among SGM in Nigeria, particularly those living with HIV. Administration of HPV vaccination before sexual debut or as a catch-up vaccination may prevent HPV-associated complications.
UR - http://www.scopus.com/inward/record.url?scp=85164412259&partnerID=8YFLogxK
U2 - 10.1371/journal.pgph.0001215
DO - 10.1371/journal.pgph.0001215
M3 - Article
AN - SCOPUS:85164412259
SN - 2767-3375
VL - 2
JO - PLOS Global Public Health
JF - PLOS Global Public Health
IS - 11 November
M1 - e0001215
ER -