Prevalence of antibodies to adenovirus serotypes 4 and 7 among unimmunized US army trainees: Results of a retrospective nationwide seroprevalence survey

Sharon L. Ludwig, John F. Brundage*, Patrick W. Kelley, Roberto Nang, Cynthia Towle, David P. Schnurr, Leta Crawford-Miksza, Joel C. Gaydos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The 1996 production halt of adenovirus types 4 and 7 vaccines prompted concerns about the resurgence of large respiratory disease outbreaks among US military basic trainees. This serosurvey was conducted to assess the current susceptibility of the trainee population to these viruses. A stratified, random sample (n = 303) of trainees' sera was tested using a quantitative calorimetric microneutralization assay to demonstrate antibody titers considered to provide immunologic protection against each adenovirus type. Results were analyzed for relationships between susceptibility and 4 demographic factors - gender, race, prior military service, and age. Results showed that 66% and 73% of trainees were susceptible to serotypes 4 and 7, respectively. Nearly 90% were susceptible to at least one serotype. Susceptibility was significantly (P < .05) related to lack of prior military service and younger age. Consistent with a serosurvey conducted 20 years ago, these results demonstrated significant susceptibility to two vaccine- preventable causes of disease. These findings may have civilian implications.

Original languageEnglish
Pages (from-to)1776-1778
Number of pages3
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - 1998

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