Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti

Michael E. von Fricken, Thomas A. Weppelmann, Will T. Eaton, Meer T. Alam, Tamar E. Carter, Laura Schick, Roseline Masse, Jean R. Romain, Bernard A. Okech*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Malaria remains a significant public health issue in Haiti, with chloroquine (CQ) used almost exclusively for the treatment of uncomplicated infections. Recently, single dose primaquine (PQ) was added to the Haitian national malaria treatment policy, despite a lack of information on the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency within the population. G6PD deficient individuals who take PQ are at risk of developing drug induced hemolysis (DIH). In this first study to examine G6PD deficiency rates in Haiti, 22.8% (range 14.9%-24.7%) of participants were found to be G6PD deficient (class I, II, or III) with 2.0% (16/800) of participants having severe deficiency (class I and II). Differences in deficiency were observed by gender, with males having a much higher prevalence of severe deficiency (4.3% vs. 0.4%) compared to females. Male participants were 1.6 times more likely to be classified as deficient and 10.6 times more likely to be classified as severely deficient compared to females, as expected. Finally, 10.6% (85/800) of the participants were considered to be at risk for DIH. Males also had much higher rates than females (19.3% vs. 4.6%) with 4.9 times greater likelihood (p value 0.000) of having an activity level that could lead to DIH. These findings provide useful information to policymakers and clinicians who are responsible for the implementation of PQ to control and manage malaria in Haiti.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalActa Tropica
Issue number1
StatePublished - Jul 2014
Externally publishedYes


  • Drug induced hemolysis
  • Glucose-6-phosphate dehydrogenase deficiency
  • Haiti
  • Malaria
  • Malaria elimination
  • Primaquine


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