TY - JOUR
T1 - Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
AU - Whitney, James B.
AU - Lim, So Yon
AU - Osuna, Christa E.
AU - Kublin, Jessica L.
AU - Chen, Elsa
AU - Yoon, Gyeol
AU - Liu, Po Ting
AU - Abbink, Peter
AU - Borducci, Erica N.
AU - Hill, Alison
AU - Lewis, Mark G.
AU - Geleziunas, Romas
AU - Robb, Merlin L.
AU - Michael, Nelson L.
AU - Barouch, Dan H.
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group). After 6 months of daily suppressive ART, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% (1 of 5), 60% (3 of 5), and 100% (5 of 5) of animals that initiated ART on days 0 (6 h), 1, 2, or 3, respectively, showed viral rebound following ART discontinuation and correlated with integrated viral DNA in lymph node CD4+ T cells. These data demonstrate that the viral reservoir is seeded within the first few days of infection and that early ART initiation limits the viral reservoir.
AB - The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group). After 6 months of daily suppressive ART, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% (1 of 5), 60% (3 of 5), and 100% (5 of 5) of animals that initiated ART on days 0 (6 h), 1, 2, or 3, respectively, showed viral rebound following ART discontinuation and correlated with integrated viral DNA in lymph node CD4+ T cells. These data demonstrate that the viral reservoir is seeded within the first few days of infection and that early ART initiation limits the viral reservoir.
UR - http://www.scopus.com/inward/record.url?scp=85058918145&partnerID=8YFLogxK
U2 - 10.1038/s41467-018-07881-9
DO - 10.1038/s41467-018-07881-9
M3 - Article
C2 - 30575753
AN - SCOPUS:85058918145
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5429
ER -