Primary adrenal insufficiency masking as an adrenal B-cell lymphoma

Eric Kuhn, John R. Sanchez, Mohamed K.M. Shakir, Thanh Duc Hoang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We report here a woman in her 70s presenting with adrenal insufficiency secondary to a primary adrenal lymphoma. The patient had a previous history of aphthous ulcers on dexamethasone and was referred to endocrinology with symptoms of fatigue and orthostasis. Subsequent Cosyntropin stimulation showed primary adrenal insufficiency and adrenal CT demonstrated large infiltrative masses. Adrenal biopsy confirmed the diagnosis of primary adrenal lymphoma of the B-cell type. This case demonstrates the importance of including lymphoma in the differential diagnosis of adrenal insufficiency, particularly in the elderly population and in the setting of negative 21-hydroxlyase antibody results.

Original languageEnglish
Article numbere250973
JournalBMJ Case Reports
Issue number9
StatePublished - 27 Sep 2022
Externally publishedYes


  • adrenal disorders
  • endocrine system
  • haematology (drugs and medicines)
  • haematology (incl blood transfusion)
  • oncology


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