Primary pleural epithelioid hemangioendothelioma (EHE) - two cases and review of the literature

Angeline Lazarus*, Gregory Fuhrer, Christina Malekiani, Sean McKay, John Thurber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We present two cases with symptoms of progressively worsening cough, dyspnea, decreased exercise tolerance and right-sided back pain in the first case and upper respiratory symptoms characterized by cough and a low grade fever in the second case.Methods: Report of two cases.Results: The initial chest X-ray in both the cases showed pleural effusion. Further imaging with computed tomography of the chest confirmed the effusion in both cases. Thoracentesis was done in both of them revealed an exudative effusion that did not reveal any infection or malignancy. Both cases underwent surgical biopsy and the diagnosis of primary pleural epithelioid hemangioendothelioma was made.Conclusions: Both the cases had progressive clinical deterioration despite chemotherapy with Taxol and Bevacizumab in one case and carboplatin, etoposide, and bevacizumab, in the second case. Both developed metastatic disease to lungs and died. Published 2010. This article is a US Government work and is in the public domain in the USA.

Original languageEnglish
Pages (from-to)e1-e5
JournalClinical Respiratory Journal
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • Computed tomography
  • Epithelioid hemangioendothelioma
  • Pleural effusion


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