Principles of antiangiogenic therapy

Cindy H. Chau*, William D. Figg

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Angiogenesis is a critical process to both tumor growth and metastasis in prostate cancer. The markers of angiogenesis in prostate cancer have been identified and could potentially provide prognostic information in addition to clinicopathological data and patient outcome. Promising preclinical studies have led to the initiation of phase I/II studies of antiangiogenic therapy in combination with docetaxel-based chemotherapy in patients with castration-resistant prostate cancer. This chapter describes the mechanisms of the angiogenic process, establishes its role in prostate cancer, and discusses the markers of angiogenesis in prostate cancer, in an attempt to provide an overall understanding of the basic principles of antiangiogenic therapy.

Original languageEnglish
Title of host publicationDrug Management of Prostate Cancer
PublisherSpringer New York
Number of pages9
ISBN (Print)9781603278317
StatePublished - 2010
Externally publishedYes


  • Angiogenesis
  • Angiogenesis inhibitor
  • Angiogenic switch
  • Antiangiogenic therapy
  • Microvessel density


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