Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection

Nicole J. Crane*, Eric A. Elster

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


The care of modern traumatic war wounds remains a significant challenge for clinicians. Many of the extremity wounds inflicted during Operation Enduring Freedom and Operation Iraqi Freedom are colonized or infected with multi-drug resistant organisms, particularly Acinetobacter baumannii. Biofilm formation and resistance to current treatments can significantly confound the wound healing process. Accurate strain identification and targeted drug administration for the treatment of wound bioburden has become a priority for combat casualty care. In this study, we use vibrational spectroscopy to examine wound exudates for bacterial load. Inherent chemical differences in different bacterial species and strains make possible the high specificity of vibrational spectroscopy.

Original languageEnglish
Title of host publicationOptical Biopsy X
StatePublished - 2012
Externally publishedYes
EventOptical Biopsy X - San Francisco, CA, United States
Duration: 24 Jan 201225 Jan 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Biopsy X
Country/TerritoryUnited States
CitySan Francisco, CA


  • Acinetobacter baumannii
  • Raman spectroscopy
  • bacteria
  • combat wounds
  • wound effluent


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