TY - JOUR
T1 - Prospecting for an HIV vaccine
AU - Brett-Major, D. M.
AU - Crowell, T. A.
AU - Michael, N. L.
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/3/24
Y1 - 2017/3/24
N2 - Human immunodeficiency virus (HIV) sets several challenges for the development of a preventative HIV vaccine. Predictable, protective natural immunity against HIV does not occur and so unlike most other diseases for which vaccines exist, there are few guideposts from natural infection. Nonetheless, six vaccine efficacy trials have occurred. One in particular, the Thai trial called RV144, showed partial protective efficacy and potential ways ahead to a better vaccine approach. This coupled with other lessons from studies of acute infections as well as an increasingly complex knowledge of HIV-related vaccine immunology bring hope that a vaccine solution might be reached for this pervasive and deadly pandemic.
AB - Human immunodeficiency virus (HIV) sets several challenges for the development of a preventative HIV vaccine. Predictable, protective natural immunity against HIV does not occur and so unlike most other diseases for which vaccines exist, there are few guideposts from natural infection. Nonetheless, six vaccine efficacy trials have occurred. One in particular, the Thai trial called RV144, showed partial protective efficacy and potential ways ahead to a better vaccine approach. This coupled with other lessons from studies of acute infections as well as an increasingly complex knowledge of HIV-related vaccine immunology bring hope that a vaccine solution might be reached for this pervasive and deadly pandemic.
KW - Human immunodeficiency virus vaccine protective efficacy immunology review
UR - http://www.scopus.com/inward/record.url?scp=85060494370&partnerID=8YFLogxK
U2 - 10.1186/s40794-017-0050-4
DO - 10.1186/s40794-017-0050-4
M3 - Review article
AN - SCOPUS:85060494370
SN - 2055-0936
VL - 3
JO - Tropical Diseases, Travel Medicine and Vaccines
JF - Tropical Diseases, Travel Medicine and Vaccines
IS - 1
M1 - 6
ER -