Prospects for a Zika Virus Vaccine

Dan H. Barouch*, Stephen J. Thomas, Nelson L. Michael

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalImmunity
Volume46
Issue number2
DOIs
StatePublished - 21 Feb 2017
Externally publishedYes

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