TY - JOUR
T1 - Protein pathway analysis in Clinical Proteomics using protein microarrays
AU - Geho, David H.
AU - Espina, Virginia
AU - Wulfkuhle, Julia
AU - Petricoin, Emanuel F.
AU - Liotta, Lance A.
AU - Milos, Patrice M.
PY - 2005
Y1 - 2005
N2 - Molecular diagnostics research within the field of cancer is increasingly focused on detecting low-abundance protein endpoints that can be used to define a patient's disease more completely. Protein microarrays represent an important Clinical Proteomics tool for directly measuring protein endpoints in samples extracted from patient tissues. By combining laser capture microdissection, arraying devices, validated isoform-specific antibodies and advanced reporter technology tools, Clinical Proteomics laboratories are currently generating molecular portraits of cancer cells harvested from patient biopsies.
AB - Molecular diagnostics research within the field of cancer is increasingly focused on detecting low-abundance protein endpoints that can be used to define a patient's disease more completely. Protein microarrays represent an important Clinical Proteomics tool for directly measuring protein endpoints in samples extracted from patient tissues. By combining laser capture microdissection, arraying devices, validated isoform-specific antibodies and advanced reporter technology tools, Clinical Proteomics laboratories are currently generating molecular portraits of cancer cells harvested from patient biopsies.
UR - http://www.scopus.com/inward/record.url?scp=30944454857&partnerID=8YFLogxK
U2 - 10.1016/j.ddtec.2005.11.008
DO - 10.1016/j.ddtec.2005.11.008
M3 - Review article
AN - SCOPUS:30944454857
SN - 1740-6749
VL - 2
SP - 353
EP - 359
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
IS - 4
ER -