Protein pathway analysis in Clinical Proteomics using protein microarrays

David H. Geho*, Virginia Espina, Julia Wulfkuhle, Emanuel F. Petricoin, Lance A. Liotta, Patrice M. Milos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Molecular diagnostics research within the field of cancer is increasingly focused on detecting low-abundance protein endpoints that can be used to define a patient's disease more completely. Protein microarrays represent an important Clinical Proteomics tool for directly measuring protein endpoints in samples extracted from patient tissues. By combining laser capture microdissection, arraying devices, validated isoform-specific antibodies and advanced reporter technology tools, Clinical Proteomics laboratories are currently generating molecular portraits of cancer cells harvested from patient biopsies.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalDrug Discovery Today: Technologies
Issue number4
StatePublished - 2005
Externally publishedYes


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