Proteins, drug targets and the mechanisms they control: The simple truth about complex networks

Robyn P. Araujo*, Lance A. Liotta, Emanuel F. Petricoin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new level of knowledge about how a drug target is wired into the control circuitry of a complex cellular network. Here we review general homeostatic principles of cellular networks that enable the cell to be resilient in the face of molecular perturbations, while at the same time being sensitive to subtle input signals. Insights into such mechanisms may facilitate the development of combination therapies that take advantage of the cellular control circuitry, with the aim of achieving higher efficacy at a lower drug dosage and with a reduced probability of drug-resistance development.

Original languageEnglish
Pages (from-to)871-880
Number of pages10
JournalNature Reviews Drug Discovery
Volume6
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

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