Proteomic approaches in cancer risk and response assessment

Emanuel F. Petricoin*, Lance A. Liotta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Proteomics is more than just a list-generating exercise where increases or decreases in protein expression are identified. Proteomic technologies will ultimately characterize information-flow through the protein circuitry that interconnects the extracellular microenvironment to the serum or plasma macroenvironment through intracellular signaling systems and their control of gene transcription. The nature of this information can be a cause or a consequence of disease processes and how patients respond to therapy. Analysis of human cancer as a model for how proteomics can have an impact at the bedside can take advantage of several promising new proteomic technologies. These technologies are being developed for early detection and risk assessment, therapeutic targeting and patient-tailored therapy.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalTrends in Molecular Medicine
Issue number2
StatePublished - Feb 2004
Externally publishedYes


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