Proteomic technologies to study diseases of the lymphatic vascular system

Lee V. Leak; Emanuel F. Petricoin; Michael Jones; Cloud P. Paweletz; Ali M. Ardekani; Vincent A. Fusaro; Sally Ross; Lance A. Liotta

doi:10.1111/j.1749-6632.2002.tb04881.x

Proteomic technologies to study diseases of the lymphatic vascular system

Lee V. Leak, Emanuel F. Petricoin, Michael Jones, Cloud P. Paweletz, Ali M. Ardekani, Vincent A. Fusaro, Sally Ross, Lance A. Liotta^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.

Original language	English
Pages (from-to)	211-228
Number of pages	18
Journal	Annals of the New York Academy of Sciences
Volume	979
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb04881.x
State	Published - 2002
Externally published	Yes

Keywords

Cancer
Laser capture microdissection
Lymph
Lymphatic endothelium
Lymphedema
Protein microarrays
Proteomics
SELDI-TOF-mass spectroscopy

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title = "Proteomic technologies to study diseases of the lymphatic vascular system",

abstract = "Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.",

keywords = "Cancer, Laser capture microdissection, Lymph, Lymphatic endothelium, Lymphedema, Protein microarrays, Proteomics, SELDI-TOF-mass spectroscopy",

author = "Leak, {Lee V.} and Petricoin, {Emanuel F.} and Michael Jones and Paweletz, {Cloud P.} and Ardekani, {Ali M.} and Fusaro, {Vincent A.} and Sally Ross and Liotta, {Lance A.}",

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pages = "211--228",

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T1 - Proteomic technologies to study diseases of the lymphatic vascular system

AU - Leak, Lee V.

AU - Petricoin, Emanuel F.

AU - Jones, Michael

AU - Paweletz, Cloud P.

AU - Ardekani, Ali M.

AU - Fusaro, Vincent A.

AU - Ross, Sally

AU - Liotta, Lance A.

PY - 2002

Y1 - 2002

N2 - Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.

AB - Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.

KW - Cancer

KW - Laser capture microdissection

KW - Lymph

KW - Lymphatic endothelium

KW - Lymphedema

KW - Protein microarrays

KW - Proteomics

KW - SELDI-TOF-mass spectroscopy

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DO - 10.1111/j.1749-6632.2002.tb04881.x

M3 - Article

C2 - 12543730

AN - SCOPUS:0036964993

SN - 0077-8923

VL - 979

SP - 211

EP - 228

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Proteomic technologies to study diseases of the lymphatic vascular system

Abstract

Keywords

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