Proteomic technologies to study diseases of the lymphatic vascular system

Lee V. Leak, Emanuel F. Petricoin, Michael Jones, Cloud P. Paweletz, Ali M. Ardekani, Vincent A. Fusaro, Sally Ross, Lance A. Liotta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.

Original languageEnglish
Pages (from-to)211-228
Number of pages18
JournalAnnals of the New York Academy of Sciences
StatePublished - 2002
Externally publishedYes


  • Cancer
  • Laser capture microdissection
  • Lymph
  • Lymphatic endothelium
  • Lymphedema
  • Protein microarrays
  • Proteomics
  • SELDI-TOF-mass spectroscopy


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