Protocol biopsies in renal transplantation: Insights into patient management and pathogenesis

M. Mengel, J. R. Chapman, F. G. Cosio, M. W. Cavaillé-Coll, H. Haller, P. F. Halloran, A. D. Kirk, M. J. Mihatsch, B. J. Nankivell, L. C. Racusen, I. S. Roberts, D. N. Rush, A. Schwarz, D. Serón, M. D. Stegall, R. B. Colvin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


A 1-day symposium on the application of protocol biopsies in renal transplantation was held in Boston, 21 July 2006. Representatives from centers with extensive experience in the use of protocol biopsies for routine patient care and research reported results on the pathological findings and their value in patient management. The consensus was that protocol biopsies, in experienced hands, are a safe and valuable means of detecting subclinical disease that can benefit from modification of therapy. Furthermore, molecular studies reveal evidence of activity or progression not readily appreciated by histological techniques. Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention.

Original languageEnglish
Pages (from-to)512-517
Number of pages6
JournalAmerican Journal of Transplantation
Issue number3
StatePublished - Mar 2007
Externally publishedYes


  • Biopsy
  • Kidney
  • Protocol
  • Rejection
  • Subclinical
  • Surrogate


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