Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners

Elisabeth A. Wilde*, Erin D. Bigler, Trevor Huff, Haonan Wang, Garrett M. Black, Zachary P. Christensen, Naomi Goodrich-Hunsaker, Jo Ann Petrie, Tracy Abildskov, Brian A. Taylor, James R. Stone, Nicholas J. Tustison, Mary R. Newsome, Harvey S. Levin, Zili D. Chu, Gerald E. York, David F. Tate

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: An important component of the multicentre Chronic Effects of Neurotrauma Consortium (CENC) project is the development of improved quantitative magnetic resonance imaging (MRI) methods, including volumetric analysis. Although many studies routinely employ quality assurance (QA) procedures including MR and human phantoms to promote accuracy and monitor site differences, few studies perform rigorous direct comparisons of these data nor report findings that enable inference regarding site-to-site comparability. These gaps in evaluating cross-site differences are concerning, especially given the well-established differences that can occur between data acquired on scanners with different manufacturer, hardware or software. Methods: This study reports findings on (1) a series of studies utilizing two MR phantoms to interrogate machine-based variability using data collected on the same magnet, (2) a human phantom repeatedly imaged on the same scanner to investigate within-subject, within-site variability and (3) a human phantom imaged on three different scanners to examine within subject, between-site variability. Results: Although variability is relatively minimal for the phantom scanned on the same magnet, significantly more variability is introduced in a human subject, particularly when regions are relatively small or multiple sites used. Conclusion: Vigilance when combining data from different sites is suggested and that future efforts address these issues.

Original languageEnglish
Pages (from-to)1442-1451
Number of pages10
JournalBrain Injury
Volume30
Issue number12
DOIs
StatePublished - 14 Oct 2016
Externally publishedYes

Keywords

  • Neuroimaging
  • brain imaging
  • magnetic resonance imaging
  • phantoms
  • veterans
  • volumetrics

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