TY - JOUR
T1 - Quantum dots for biomedical applications
AU - Signore, Michele
AU - Liotta, Lance A.
AU - De Maria, Ruggero
AU - Petricoin, Emanuel F.
PY - 2008/3
Y1 - 2008/3
N2 - Background: Nanotechnology is an emerging field that could have a significant impact on cancer diagnosis, treatment and analysis. Quantum dots represent one of the most interesting nanotechnology-based platforms, and their unique properties make them a potentially versatile tool for molecular diagnostics. Objectives: Here, the most promising uses of quantum dots for translational research are reviewed, ranging from multiplexed immunofluorescence, targeted drug delivery coupled with disease visualization, tumor and sentinel organs localization and long-term cell tracing. Finally, potential future directions for quantum dots as both a diagnostic and therapeutic tool in biomedical research will be explored. Conclusions: The use of quantum dots in biomedical applications is accelerating owing to their unique physical attributes, imaging capabilities, and potential for therapeutic delivery.
AB - Background: Nanotechnology is an emerging field that could have a significant impact on cancer diagnosis, treatment and analysis. Quantum dots represent one of the most interesting nanotechnology-based platforms, and their unique properties make them a potentially versatile tool for molecular diagnostics. Objectives: Here, the most promising uses of quantum dots for translational research are reviewed, ranging from multiplexed immunofluorescence, targeted drug delivery coupled with disease visualization, tumor and sentinel organs localization and long-term cell tracing. Finally, potential future directions for quantum dots as both a diagnostic and therapeutic tool in biomedical research will be explored. Conclusions: The use of quantum dots in biomedical applications is accelerating owing to their unique physical attributes, imaging capabilities, and potential for therapeutic delivery.
KW - Cancer
KW - Imaging
KW - Molecular diagnostics
KW - Proteomics
KW - Quantum dots
KW - Reserve-phase array
UR - http://www.scopus.com/inward/record.url?scp=77953406175&partnerID=8YFLogxK
U2 - 10.1517/17530059.2.3.315
DO - 10.1517/17530059.2.3.315
M3 - Review article
AN - SCOPUS:77953406175
SN - 1753-0059
VL - 2
SP - 315
EP - 322
JO - Expert Opinion on Medical Diagnostics
JF - Expert Opinion on Medical Diagnostics
IS - 3
ER -