Rabbit urethral regeneration using small intestinal submucosa onlay grafts

Bradley P. Kropp; John K. Ludlow; Donald Spicer; Marian K. Rippy; Stephen F. Badylak; Mark C. Adams; Michael A. Keating; Richard C. Rink; Richard Birhle; Karl B. Thor

doi:10.1016/S0090-4295(98)00114-9

Rabbit urethral regeneration using small intestinal submucosa onlay grafts

Bradley P. Kropp^*, John K. Ludlow, Donald Spicer, Marian K. Rippy, Stephen F. Badylak, Mark C. Adams, Michael A. Keating, Richard C. Rink, Richard Birhle, Karl B. Thor

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

192 Scopus citations

Abstract

Objectives. To determine if small intestinal submucosa (SIS) can evoke urethral regeneration. Methods. Twenty male white New Zealand rabbits were assigned to one of three experimental groups. Group 1 (n = 4) underwent simple urethrotomy and closure. Group 2 (n = 8), a second control group, underwent an onlay urethroplasty with a graft of full-thickness preputial skin from the host rabbit. Group 3 (n = 8) underwent an onlay urethroplasty with an SIS graft. Results. All eight SIS onlay grafts promoted regeneration of the normal rabbit epithelium supported by a well-vascularized collagen and smooth muscle backing. Preputial free onlay grafts maintained a keratinizing squamous cell epithelium with a poor supportive backing, which resulted in the formation of urethral diverticulum. Conclusions. SIS onlay patch grafts for urethroplasty promote rabbit urethral regeneration.

Original language	English
Pages (from-to)	138-142
Number of pages	5
Journal	Urology
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/S0090-4295(98)00114-9
State	Published - Jul 1998

Access to Document

10.1016/S0090-4295(98)00114-9

Cite this

@article{4b8fa539d42b4e1abc04fcd7df500a81,

title = "Rabbit urethral regeneration using small intestinal submucosa onlay grafts",

abstract = "Objectives. To determine if small intestinal submucosa (SIS) can evoke urethral regeneration. Methods. Twenty male white New Zealand rabbits were assigned to one of three experimental groups. Group 1 (n = 4) underwent simple urethrotomy and closure. Group 2 (n = 8), a second control group, underwent an onlay urethroplasty with a graft of full-thickness preputial skin from the host rabbit. Group 3 (n = 8) underwent an onlay urethroplasty with an SIS graft. Results. All eight SIS onlay grafts promoted regeneration of the normal rabbit epithelium supported by a well-vascularized collagen and smooth muscle backing. Preputial free onlay grafts maintained a keratinizing squamous cell epithelium with a poor supportive backing, which resulted in the formation of urethral diverticulum. Conclusions. SIS onlay patch grafts for urethroplasty promote rabbit urethral regeneration.",

author = "Kropp, {Bradley P.} and Ludlow, {John K.} and Donald Spicer and Rippy, {Marian K.} and Badylak, {Stephen F.} and Adams, {Mark C.} and Keating, {Michael A.} and Rink, {Richard C.} and Richard Birhle and Thor, {Karl B.}",

year = "1998",

month = jul,

doi = "10.1016/S0090-4295(98)00114-9",

language = "English",

volume = "52",

pages = "138--142",

journal = "Urology",

issn = "0090-4295",

number = "1",

}

TY - JOUR

T1 - Rabbit urethral regeneration using small intestinal submucosa onlay grafts

AU - Kropp, Bradley P.

AU - Ludlow, John K.

AU - Spicer, Donald

AU - Rippy, Marian K.

AU - Badylak, Stephen F.

AU - Adams, Mark C.

AU - Keating, Michael A.

AU - Rink, Richard C.

AU - Birhle, Richard

AU - Thor, Karl B.

PY - 1998/7

Y1 - 1998/7

N2 - Objectives. To determine if small intestinal submucosa (SIS) can evoke urethral regeneration. Methods. Twenty male white New Zealand rabbits were assigned to one of three experimental groups. Group 1 (n = 4) underwent simple urethrotomy and closure. Group 2 (n = 8), a second control group, underwent an onlay urethroplasty with a graft of full-thickness preputial skin from the host rabbit. Group 3 (n = 8) underwent an onlay urethroplasty with an SIS graft. Results. All eight SIS onlay grafts promoted regeneration of the normal rabbit epithelium supported by a well-vascularized collagen and smooth muscle backing. Preputial free onlay grafts maintained a keratinizing squamous cell epithelium with a poor supportive backing, which resulted in the formation of urethral diverticulum. Conclusions. SIS onlay patch grafts for urethroplasty promote rabbit urethral regeneration.

AB - Objectives. To determine if small intestinal submucosa (SIS) can evoke urethral regeneration. Methods. Twenty male white New Zealand rabbits were assigned to one of three experimental groups. Group 1 (n = 4) underwent simple urethrotomy and closure. Group 2 (n = 8), a second control group, underwent an onlay urethroplasty with a graft of full-thickness preputial skin from the host rabbit. Group 3 (n = 8) underwent an onlay urethroplasty with an SIS graft. Results. All eight SIS onlay grafts promoted regeneration of the normal rabbit epithelium supported by a well-vascularized collagen and smooth muscle backing. Preputial free onlay grafts maintained a keratinizing squamous cell epithelium with a poor supportive backing, which resulted in the formation of urethral diverticulum. Conclusions. SIS onlay patch grafts for urethroplasty promote rabbit urethral regeneration.

UR - http://www.scopus.com/inward/record.url?scp=0032126749&partnerID=8YFLogxK

U2 - 10.1016/S0090-4295(98)00114-9

DO - 10.1016/S0090-4295(98)00114-9

M3 - Article

C2 - 9671888

AN - SCOPUS:0032126749

SN - 0090-4295

VL - 52

SP - 138

EP - 142

JO - Urology

JF - Urology

IS - 1

ER -

Rabbit urethral regeneration using small intestinal submucosa onlay grafts

Abstract

Access to Document

Fingerprint

Cite this