Randomized Clinical Trials in Gastrointestinal Stromal Tumors

Peter A. Learn; Jason K. Sicklick; Ronald P. DeMatteo

doi:10.1016/j.soc.2009.09.004

Randomized Clinical Trials in Gastrointestinal Stromal Tumors

Peter A. Learn, Jason K. Sicklick, Ronald P. DeMatteo^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Gastrointestinal (GI) stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract, constituting 80% of all GI mesenchymal tumors and approximately 20% of all small bowel malignancies, excluding lymphomas. This article provides a summary of recent randomized clinical trials of these tumors.

Original language	English
Pages (from-to)	101-113
Number of pages	13
Journal	Surgical Oncology Clinics of North America
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.soc.2009.09.004
State	Published - Jan 2010
Externally published	Yes

Keywords

Disease-free survival
Gastrointestinal stromal tumor
Recurrence-free survival

Access to Document

10.1016/j.soc.2009.09.004

Cite this

@article{efb877bdb03b453b992f872095d3f3d0,

title = "Randomized Clinical Trials in Gastrointestinal Stromal Tumors",

abstract = "Gastrointestinal (GI) stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract, constituting 80% of all GI mesenchymal tumors and approximately 20% of all small bowel malignancies, excluding lymphomas. This article provides a summary of recent randomized clinical trials of these tumors.",

keywords = "Disease-free survival, Gastrointestinal stromal tumor, Recurrence-free survival",

author = "Learn, {Peter A.} and Sicklick, {Jason K.} and DeMatteo, {Ronald P.}",

note = "Funding Information: 1. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. Demetri GD, von Mehren M, Blanke CD, et al. N Engl J Med 2002 Aug 15; 347(7):472–80. 11 Hypothesis : Imatinib, evaluated at two different dose regimens, improves PFS in patients with unresectable or metastatic GIST beyond historical expectations. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 147 400 mg imatinib daily n = 73 600 mg imatinib daily n = 74 None No difference in PFS P = not significant Published abstract : BACKGROUND: Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of GISTs. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors. METHODS: The authors conducted an open-label, randomized, multicenter trial to evaluate the activity of imatinib in patients with advanced gastrointestinal stromal tumor. They assessed antitumor response and the safety and tolerability of the drug. Pharmacokinetics were assessed in a subgroup of patients. RESULTS: One-hundred forty-seven patients were randomly assigned to receive 400 mg or 600 mg of imatinib daily. Overall, 79 patients (53.7%) had a partial response; 41 patients (27.9%) had stable disease, and for technical reasons, response could not be evaluated in 7 patients (4.8%). No patient had a complete response to the treatment. The median duration of response had not been reached after a median follow-up of 24 weeks after the onset of response. Early resistance to imatinib was noted in 20 patients (13.6%). Therapy was tolerated well, although mild-to-moderate edema, diarrhea, and fatigue were common. GI or intra-abdominal hemorrhage occurred in approximately 5% of patients. There were no significant differences in toxic effects or response between the two doses. Imatinib was absorbed well, with pharmacokinetics similar to those reported in patients with chronic myeloid leukemia. CONCLUSIONS: Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic GIST. Inhibition of the KIT signal transduction pathway is a promising treatment for advanced GISTS that resist conventional chemotherapy. (Copyright [2002] Massachusetts Medical Society. All rights reserved.) ). Editor's summary and comments : In this seminal, multicenter, phase 2 study, Demetri and colleagues demonstrated the unprecedented efficacy of imatinib in unresectable or metastatic KIT-positive GIST. Beginning as a proof-of-concept study, promising early results prompted expanded enrollment. Following a 6-month follow-up of the first 100 patients, interim analysis demonstrated no difference in PFS but illustrated a dramatic response over historical expectations. The study was closed as enrollment into a phase 3trial was initiated. Of the 147 patients enrolled, 120 patients (81.6%) demonstrated either disease regression or stabilization. Although differences in efficacy were not observed between the two administered doses, the vast improvements in overall survival and PFS seen in both arms over historical controls established the benefits of imatinib in advanced GIST. In a subsequent follow-up study, 12 the investigators demonstrated the sustained benefit of imatinib administered at either dose. With longer follow-up, objective radiological responses, as determined by Response Evaluation Criteria In Solid Tumors (RECIST) criteria, increased from 54% to 68%. More importantly, survival was shown to be independent of the extent of response, such that patients with partial responses or with stable disease experienced similar survival benefits. This may reflect the inadequacy of RECIST criteria in categorizing responses to molecular therapy. More specifically, changes in tumor density do not always correlate with alterations in tumor size ( Fig. 1 20 2. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. Blanke CD, Rankin C, Demetri GD, et al. J Clin Oncol 2008 Feb 1;26(4):626–32. 13 Hypothesis : High-dose imatinib (400 mg twice daily) achieves better PFS and overall survival than conventional-dose imatinib (400 mg once daily). # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 746 Imatinib 400 mg daily n = 345 Imatinib 400 mg twice daily n = 349 By Zubrod performance status (0–2 versus 3) and by disease status (measurable versus unmeasurable) No significant differences in PFS or overall survival P = not significant Published abstract : PURPOSE: To assess potential differences in PFS or overall survival when imatinib mesylate is administered to patients with incurable GIST at a standard dose (400 mg daily) versus a high dose (400 mg twice daily). PATIENTS AND METHODS: Patients with metastatic or surgically unresectable GIST were eligible for this phase 3 open-label clinical trial. At registration, patients were assigned randomly to either standard or high-dose imatinib, with close-interval follow-up. If objective progression occurred by RECIST, patients on the standard-dose arm could reregister to the trial and receive the high-dose imatinib regimen. RESULTS: Seven hundred forty-six patients with advanced GIST from 148 centers across the United States and Canada were enrolled onto this trial in 9 months. With a median follow-up of 4.5 years, median PFS was 18 months for patients on the standard-dose arm and 20 months for those receiving high-dose imatinib. Median overall survival was 55 and 51 months, respectively. There were no statistically significant differences in objective response rates, PFS, or overall survival. After progression on standard-dose imatinib, 33% of patients who crossed over to the high-dose imatinib regimen achieved either an objective response or stable disease. There were more grade 3, 4, and 5 toxicities noted on the high-dose imatinib arm. CONCLUSION: This trial confirms the effectiveness of imatinib as primary systemic therapy for patients with incurable GIST but did not show any advantage to higher dose treatment. It appears reasonable to initiate therapy with 400 mg daily and to consider dose escalation on progression of disease. (Copyright [2008] American Society of Clinical Oncology, reprinted with permission.) Editor's summary and comments : This multicenter, phase 3 trial was designed to investigate the appropriate dose of imatinib in patients with surgically incurable GIST, following on results of the earlier phase 2 trial. Imatinib was tolerated fairly well at both doses, although dose reductions and grade 3 to 5 toxicities were more common in the high-dose arm. No significant differences were identified in PFS or overall survival on intention-to-treat analyses. Of the 133 patients who crossed over, however, 118 could be assessed for response, and among these, median PFS was 5 months. These results suggest a possible benefit to increasing treatment dose consequent to conventional dose failure. Based on the results of this study, it is reasonable to presume that conventional-dose imatinib is appropriate for most patients, with high-dose therapy reserved for patients progressing on a conventional dose. 3. Progression-free survival in gastrointestinal stromal tumors with high-dose imatinib: randomized trial. Verweij J, Casali PG, Zalcberg J, et al. Lancet 2004 Sep 25-Oct 1;364(9440):1127–34. 7 Hypothesis : High-dose imatinib (400 mg twice daily) achieves better PFS than low-dose imatinib (400 mg once daily). # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 946 400 mg imatinib once daily n = 473 400 mg imatinib twice daily n = 473 None 400 mg imatinib daily results in partial response of disease while a dose of 400 mg imatinib twice daily improves PFS PFS: hazard ratio (HR) 0.82 (95% confidence interval (CI) 0.69–0.98, P = .026) Published abstract : BACKGROUND: Imatinib is approved worldwide for use in GISTs. The authors aimed to assess dose dependency of response and PFS with imatinib for metastatic GIST. METHODS: Nine-hundred forty-six patients were allocated randomly imatinib 400 mg either once or twice a day. Those assigned the once-a-day regimen who had progression were offered the option of crossover. The primary endpoint was PFS. Analysis was by intention to treat. FINDINGS: At median follow-up of 760 days (interquartile range [IQR] 644-859), 263 (56%) of 473 patients allocated imatinib once daily had progressed compared with 235 (50%) of 473 patients who were assigned treatment twice daily (estimated hazard ratio [HR] 0.82 [95% CI 0.69 to 0.98]; P = .026). Side effects arose in 465 of 470 (99%) patients allocated the once-daily regimen compared with 468 of 472 (99%) assigned treatment twice daily. By comparison with the group treated once daily, more dose reductions (77 [16%] versus 282 [60%]) and treatment interruptions (189 [40%] versus 302 [64%]) were recorded in patients allocated the twice-daily regimen, but treatment in both arms was tolerated fairly well. Fifty-two (5%) patients achieved a complete response, 442 (47%) a partial response, and 300 (32%) stable disease, with no difference between groups. Median time to best response was 107 days (IQR 58-172). INTERPRETATION: If response induction is the only aim of treatment, a daily dose of 400 mg of imatinib is sufficient; however, a dose of 400 mg twice a day achieves significantly longer PFS. (Copyright [2004] Elsevier.) Editor's summary and comments : The European Organization for Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG), and the Australasian Gastrointestinal Trials Group (AGITG) performed a worldwide, prospective, randomized trial to investigate once- versus twice-daily imatinib for metastatic GIST. At a median follow-up of just over 2 years, only 6% fewer patients had disease progression with the twice-daily dosing. While this did translate into a statistically significant increase in PFS, the effect was modest. Patients in the higher-dose arm had slightly more dose reductions and treatment interruptions because of toxicities. Moreover, in the intention-to-treat analysis, treatment responses were remarkably similar between the two treatment groups. This trial both suggests that a lower dose of imatinib is adequate for treatment if a response is seen and establishes 400 mg daily as the standard dose of imatinib for treating advanced GIST. A subsequent follow-up study 14 evaluated the feasibility, safety, and efficacy of crossing-over from low-dose to high-dose imatinib upon progression of disease. Of the patients possible for crossover, 55% (133 of 241 patients) crossed over. Although toxicities were often not high grade, slightly more than half of patients did not tolerate the dose escalation. Crossover resulted in a 33% increase in time to progression. Based on this post-hoc analysis, crossover to high-dose imatinib is feasible and safe in GIST patients who progress on low-dose therapy, and it also appears to delay disease progression, suggesting that there is therapeutic utility to an imatinib dose increase in patients with progression of disease. 4. Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group. Blay JY, Le Cesne A, Ray-Coquard I, et al. J Clin Oncol 2007 Mar 20;25(9):1107–13. 16 Hypothesis : Continuous imatinib improves PFS in patients with advanced GIST as compared with interrupted imatinib beyond 1 year of treatment. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 58 Interrupted imatinib n = 32 Continuous imatinib n = 26 None Improvement in PFS with continuous imatinib therapy versus interrupted imatinib therapy Median PFS 18 months (95% CI 15.0–23.6) versus 6.1 months (95% CI 3.5–9.7), P <.0001) Published abstract : PURPOSE: Imatinib is the standard treatment of advanced GISTs. It is not known whether imatinib may be stopped in patients in whom disease is controlled. METHODS: This prospective, randomized, multicentric phase 3 study was designed to compare continuous with interrupted imatinib beyond 1 year of treatment in patients with advanced GIST. The primary end point was PFS. Secondary end points included overall survival, response rate after reinitiation of imatinib, and quality of life. Early stopping rules in cases of rapid progression of disease were defined, with preplanned interim analyses. RESULTS: Between May 2002 and April 2004, 182 patients with advanced GIST were enrolled. Between May 2003 and April 2004, 98 patients in response or stable disease under imatinib reached more than 1 year of follow-up. Forty patients were not eligible for randomization, and 58 patients were randomly assigned, 32 and 26 patients in the interrupted and continuous arms, respectively. As of Oct. 15, 2005, 8 of 26 patients in the continuous group and 26 of 32 patients in the interrupted group had documented disease progression ( P <.0001). Twenty-four of 26 patients with documented progression in the interrupted arm responded to imatinib reintroduction. No differences in overall survival or imatinib resistance were observed between the two arms. Quality of life evaluated 6 months after random assignment using the 30-item quality of life questionnaire was not significantly different between the two groups of randomly assigned patients. CONCLUSION: Imatinib interruption results in rapid progression in most patients with advanced GIST, and cannot be recommended in routine practice unless patients experience significant toxicity. (Copyright [2007] American Society of Clinical Oncology, reprinted with permission.) Editor's summary and comments : This prospective, randomized, multicenter phase 3 trial was designed to determine whether imatinib therapy may be discontinued in patients whose disease is controlled following 1 year of treatment. The data suggested that therapy should be administered without interruption. During a 2-year period, 182 patients were enrolled. Following 1 year of treatment with imatinib, patients with metastatic or unresectable GIST who had either stable or partially responsive disease randomly were assigned either to continue or to discontinue imatinib therapy. Patients who were randomized to interrupted therapy were able to cross over to the treatment arm if they had progression of disease. Of this arm, 81% (26 of 32 patients) crossed over. Of these patients, 92% (24 of 26) responded to reintroduction of therapy. This suggested that even if there is no disease seen on a computed tomography (CT) scan, viable microscopic disease remains after imatinib therapy. Lending further validity to this concept, no patients in the continuous treatment arm had progression of disease at undetectable disease sites. Although there was no difference in overall survival, Imatinib resistance, or quality of life, continuous treatment resulted in a significantly longer PFS. This trial affirmed that imatinib therapy should not be sporadic and demonstrated that for patients wherein imatinib is discontinued, early progression is expected. 5. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomized controlled trial. Demetri GD, van Oosterom AT, Garrett CR, et al. Lancet 2006 Oct 14; 368(9544):1329–38. 17 Hypothesis : Sunitinib improves PFS in patients with unresectable GIST who have failed imatinib therapy compared with placebo. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 312 Sunitinib n = 207 Placebo n = 105 Based on prior outcome on imatinib treatment: progression within 6 months versus progression beyond 6 months or intolerance to imatinib Improvement in PFS Hazard ratio 0.33 (95% CI 0.23–0.47, P <.0001) Published abstract : BACKGROUND: No effective therapeutic options for patients with unresectable imatinib-resistant GIST are available. The authors did a randomized, double-blind, placebo-controlled, multicenter, international trial to assess tolerability and anticancer efficacy of sunitinib, a multitargeted tyrosine kinase inhibitor, in patients with advanced GIST who were resistant to or intolerant of previous treatment with imatinib. METHODS: Blinded sunitinib or placebo was given orally once daily at a 50-mg starting dose in 6-week cycles, with 4 weeks on and 2 weeks off treatment. The primary endpoint was time to tumor progression. Intention-to-treat, modified intention-to-treat, and per-protocol analyses were done. This study is registered at http://www.ClinicalTrials.gov , number NCT00075218. FINDINGS: Three hundred-twelve patients were randomized in a 2:1 ratio to receive sunitinib (n = 207) or placebo (n = 105); the trial was unblinded early when a planned interim analysis showed significantly longer time to tumor progression with sunitinib. Median time to tumor progression was 27.3 weeks (95% CI 16.0 to 32.1) in patients receiving sunitinib and 6.4 weeks (95% CI 4.4 to 10.0) in those on placebo (HR 0.33; P <.0001). Therapy was tolerated reasonably well; the most common treatment-related adverse events were fatigue, diarrhea, skin discoloration, and nausea. INTERPRETATION: The authors noted significant clinical benefit, including disease control and superior survival, with sunitinib compared with placebo in patients with advanced GIST after failure and discontinuation of imatinib. Tolerability was acceptable. (Copyright [2006] Elsevier.) Editor's summary and comments : In this international trial involving 56 centers, Demetri and colleagues validated the efficacy of sunitinib as a second-line therapy in advanced GIST. Patients who had failed imatinib therapy, either by disease progression or drug intolerance, were enrolled. Initially powered to detect a 50% improvement in median PFS, the study was unblinded early after a planned interim analysis. Using intention-to-treat analysis, PFS was superior in the sunitinib arm, extending the median time to progression by over 4 months. The threshold for difference in outcome was low, because sunitinib was being compared with placebo. Although not designed to evaluate overall survival, early data suggested an overall survival advantage in the sunitinib arm (HR of death 0.49, 95% CI 0.29 to 0.83). Given the limited options for patients who fail imatinib therapy, this study affirmed the viability of sunitinib as a second-line therapy. 6. Adjuvant imatinib mesylate after resection of localized, primary gastrointestinal stromal tumor: a randomized, double-blind, placebo-controlled trial. Dematteo RP, Ballman KV, Antonescu CR, et al. Lancet 2009 Mar 28;373(9669):1097–104. 18 Hypothesis : Imatinib 400 mg daily administered for 1 year after complete resection of localized, primary GIST improves recurrence-free survival over placebo. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 713 Imatinib 400 mg daily n = 359 Placebo n = 354 By tumor size: ≥3–<6 cm, ≥6–<10 cm, or ≥10 cm Improvement in recurrence-free survival HR 0.35 (95% CI 0.22–0.53, P <.0001) Published abstract : BACKGROUND: GIST is the most common sarcoma of the intestinal tract. Imatinib mesylate is a small molecule that inhibits activation of the KIT and PDGFRα proteins, and is effective in first-line treatment of metastatic GIST. The authors postulated that adjuvant treatment with imatinib would improve recurrence-free survival compared with placebo after resection of localized, primary GIST. METHODS: The authors undertook a randomized phase 3, double-blind, placebo-controlled, multicenter trial. Eligible patients had complete gross resection of a primary GIST at least 3 cm in size and positive for the KIT protein by immunohistochemistry. Patients were randomly assigned, by a stratified biased coin design, to imatinib 400 mg (n = 359) or to placebo (n = 354) daily for 1 year after surgical resection. Patients and investigators were blinded to the treatment group. Patients assigned to placebo were eligible to cross over to imatinib treatment in the event of tumor recurrence. The primary endpoint was recurrence-free survival, and analysis was by intention to treat. Accrual was stopped early, because the trial results crossed the interim analysis efficacy boundary for recurrence-free survival. This study is registered with http://www.ClinicalTrials.gov , number NCT00041197. FINDINGS: All randomized patients were included in the analysis. At median follow-up of 19.7 months (range 0 to 56.4 months), 30 (8%) patients in the imatinib group and 70 (20%) in the placebo group had tumor recurrence or died. Imatinib significantly improved recurrence-free survival compared with placebo (98% [95% CI 96 to 100] versus 83% [95% CI 78 to 88] at 1 year; HR 0.35 [0.22 to 0.53]; one-sided P <.0001). Adjuvant imatinib was tolerated well, with the most common serious events being dermatitis (11 [3%] versus 0), abdominal pain (12 [3%] versus 6 [1%]), and diarrhea (10 [2%] versus 5 [1%]) in the imatinib group and hyperglycemia (two [<1%] versus seven [2%]) in the placebo group. INTERPRETATION: Adjuvant imatinib therapy is safe and seems to improve recurrence-free survival compared with placebo after the resection of primary GIST. FUNDING: Funding was provided by the US National Institutes of Health and Novartis Pharmaceuticals. (Copyright [2009] Elsevier.) ). Editor's summary and comments : While all other randomized controlled trials to date have explored the use of therapies in surgically incurable GIST, DeMatteo and colleagues evaluated the use of imatinib in an adjuvant setting, recognizing the significant risk of tumor recurrence following complete surgical resection. This trial originally was designed with overall survival as the primary end point, at a time when the efficacy of imatinib in advanced GIST had not yet been recognized fully. As the efficacy of imatinib became apparent, the study was redesigned to detect a 40% improvement in recurrence-free survival with a 90% power. The trial was closed early after interim analysis demonstrated efficacy in the therapy arm. With a median follow-up of nearly 20 months, a clear improvement in recurrence-free survival in the treatment arm was demonstrated. This effect was observed across all groups of the trial stratification. Differences in overall survival have not been demonstrated so far. In addition, the recurrence rate in the imatinib group was noted to increase appreciably around 18 months after surgery, raising the concern that 1 year of therapy may be inadequate for patients at high risk for recurrence. Although this study clearly demonstrates that empiric adjuvant imatinib reduces the rates of early recurrence, it is not yet clear whether this strategy improves overall survival over a strategy of watchful waiting. Furthermore, optimal patient selection criteria remain to be determined ( Fig. 2 ",

year = "2010",

month = jan,

doi = "10.1016/j.soc.2009.09.004",

language = "English",

volume = "19",

pages = "101--113",

journal = "Surgical Oncology Clinics of North America",

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TY - JOUR

T1 - Randomized Clinical Trials in Gastrointestinal Stromal Tumors

AU - Learn, Peter A.

AU - Sicklick, Jason K.

AU - DeMatteo, Ronald P.

N1 - Funding Information: 1. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. Demetri GD, von Mehren M, Blanke CD, et al. N Engl J Med 2002 Aug 15; 347(7):472–80. 11 Hypothesis : Imatinib, evaluated at two different dose regimens, improves PFS in patients with unresectable or metastatic GIST beyond historical expectations. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 147 400 mg imatinib daily n = 73 600 mg imatinib daily n = 74 None No difference in PFS P = not significant Published abstract : BACKGROUND: Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of GISTs. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors. METHODS: The authors conducted an open-label, randomized, multicenter trial to evaluate the activity of imatinib in patients with advanced gastrointestinal stromal tumor. They assessed antitumor response and the safety and tolerability of the drug. Pharmacokinetics were assessed in a subgroup of patients. RESULTS: One-hundred forty-seven patients were randomly assigned to receive 400 mg or 600 mg of imatinib daily. Overall, 79 patients (53.7%) had a partial response; 41 patients (27.9%) had stable disease, and for technical reasons, response could not be evaluated in 7 patients (4.8%). No patient had a complete response to the treatment. The median duration of response had not been reached after a median follow-up of 24 weeks after the onset of response. Early resistance to imatinib was noted in 20 patients (13.6%). Therapy was tolerated well, although mild-to-moderate edema, diarrhea, and fatigue were common. GI or intra-abdominal hemorrhage occurred in approximately 5% of patients. There were no significant differences in toxic effects or response between the two doses. Imatinib was absorbed well, with pharmacokinetics similar to those reported in patients with chronic myeloid leukemia. CONCLUSIONS: Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic GIST. Inhibition of the KIT signal transduction pathway is a promising treatment for advanced GISTS that resist conventional chemotherapy. (Copyright [2002] Massachusetts Medical Society. All rights reserved.) ). Editor's summary and comments : In this seminal, multicenter, phase 2 study, Demetri and colleagues demonstrated the unprecedented efficacy of imatinib in unresectable or metastatic KIT-positive GIST. Beginning as a proof-of-concept study, promising early results prompted expanded enrollment. Following a 6-month follow-up of the first 100 patients, interim analysis demonstrated no difference in PFS but illustrated a dramatic response over historical expectations. The study was closed as enrollment into a phase 3trial was initiated. Of the 147 patients enrolled, 120 patients (81.6%) demonstrated either disease regression or stabilization. Although differences in efficacy were not observed between the two administered doses, the vast improvements in overall survival and PFS seen in both arms over historical controls established the benefits of imatinib in advanced GIST. In a subsequent follow-up study, 12 the investigators demonstrated the sustained benefit of imatinib administered at either dose. With longer follow-up, objective radiological responses, as determined by Response Evaluation Criteria In Solid Tumors (RECIST) criteria, increased from 54% to 68%. More importantly, survival was shown to be independent of the extent of response, such that patients with partial responses or with stable disease experienced similar survival benefits. This may reflect the inadequacy of RECIST criteria in categorizing responses to molecular therapy. More specifically, changes in tumor density do not always correlate with alterations in tumor size ( Fig. 1 20 2. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. Blanke CD, Rankin C, Demetri GD, et al. J Clin Oncol 2008 Feb 1;26(4):626–32. 13 Hypothesis : High-dose imatinib (400 mg twice daily) achieves better PFS and overall survival than conventional-dose imatinib (400 mg once daily). # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 746 Imatinib 400 mg daily n = 345 Imatinib 400 mg twice daily n = 349 By Zubrod performance status (0–2 versus 3) and by disease status (measurable versus unmeasurable) No significant differences in PFS or overall survival P = not significant Published abstract : PURPOSE: To assess potential differences in PFS or overall survival when imatinib mesylate is administered to patients with incurable GIST at a standard dose (400 mg daily) versus a high dose (400 mg twice daily). PATIENTS AND METHODS: Patients with metastatic or surgically unresectable GIST were eligible for this phase 3 open-label clinical trial. At registration, patients were assigned randomly to either standard or high-dose imatinib, with close-interval follow-up. If objective progression occurred by RECIST, patients on the standard-dose arm could reregister to the trial and receive the high-dose imatinib regimen. RESULTS: Seven hundred forty-six patients with advanced GIST from 148 centers across the United States and Canada were enrolled onto this trial in 9 months. With a median follow-up of 4.5 years, median PFS was 18 months for patients on the standard-dose arm and 20 months for those receiving high-dose imatinib. Median overall survival was 55 and 51 months, respectively. There were no statistically significant differences in objective response rates, PFS, or overall survival. After progression on standard-dose imatinib, 33% of patients who crossed over to the high-dose imatinib regimen achieved either an objective response or stable disease. There were more grade 3, 4, and 5 toxicities noted on the high-dose imatinib arm. CONCLUSION: This trial confirms the effectiveness of imatinib as primary systemic therapy for patients with incurable GIST but did not show any advantage to higher dose treatment. It appears reasonable to initiate therapy with 400 mg daily and to consider dose escalation on progression of disease. (Copyright [2008] American Society of Clinical Oncology, reprinted with permission.) Editor's summary and comments : This multicenter, phase 3 trial was designed to investigate the appropriate dose of imatinib in patients with surgically incurable GIST, following on results of the earlier phase 2 trial. Imatinib was tolerated fairly well at both doses, although dose reductions and grade 3 to 5 toxicities were more common in the high-dose arm. No significant differences were identified in PFS or overall survival on intention-to-treat analyses. Of the 133 patients who crossed over, however, 118 could be assessed for response, and among these, median PFS was 5 months. These results suggest a possible benefit to increasing treatment dose consequent to conventional dose failure. Based on the results of this study, it is reasonable to presume that conventional-dose imatinib is appropriate for most patients, with high-dose therapy reserved for patients progressing on a conventional dose. 3. Progression-free survival in gastrointestinal stromal tumors with high-dose imatinib: randomized trial. Verweij J, Casali PG, Zalcberg J, et al. Lancet 2004 Sep 25-Oct 1;364(9440):1127–34. 7 Hypothesis : High-dose imatinib (400 mg twice daily) achieves better PFS than low-dose imatinib (400 mg once daily). # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 946 400 mg imatinib once daily n = 473 400 mg imatinib twice daily n = 473 None 400 mg imatinib daily results in partial response of disease while a dose of 400 mg imatinib twice daily improves PFS PFS: hazard ratio (HR) 0.82 (95% confidence interval (CI) 0.69–0.98, P = .026) Published abstract : BACKGROUND: Imatinib is approved worldwide for use in GISTs. The authors aimed to assess dose dependency of response and PFS with imatinib for metastatic GIST. METHODS: Nine-hundred forty-six patients were allocated randomly imatinib 400 mg either once or twice a day. Those assigned the once-a-day regimen who had progression were offered the option of crossover. The primary endpoint was PFS. Analysis was by intention to treat. FINDINGS: At median follow-up of 760 days (interquartile range [IQR] 644-859), 263 (56%) of 473 patients allocated imatinib once daily had progressed compared with 235 (50%) of 473 patients who were assigned treatment twice daily (estimated hazard ratio [HR] 0.82 [95% CI 0.69 to 0.98]; P = .026). Side effects arose in 465 of 470 (99%) patients allocated the once-daily regimen compared with 468 of 472 (99%) assigned treatment twice daily. By comparison with the group treated once daily, more dose reductions (77 [16%] versus 282 [60%]) and treatment interruptions (189 [40%] versus 302 [64%]) were recorded in patients allocated the twice-daily regimen, but treatment in both arms was tolerated fairly well. Fifty-two (5%) patients achieved a complete response, 442 (47%) a partial response, and 300 (32%) stable disease, with no difference between groups. Median time to best response was 107 days (IQR 58-172). INTERPRETATION: If response induction is the only aim of treatment, a daily dose of 400 mg of imatinib is sufficient; however, a dose of 400 mg twice a day achieves significantly longer PFS. (Copyright [2004] Elsevier.) Editor's summary and comments : The European Organization for Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG), and the Australasian Gastrointestinal Trials Group (AGITG) performed a worldwide, prospective, randomized trial to investigate once- versus twice-daily imatinib for metastatic GIST. At a median follow-up of just over 2 years, only 6% fewer patients had disease progression with the twice-daily dosing. While this did translate into a statistically significant increase in PFS, the effect was modest. Patients in the higher-dose arm had slightly more dose reductions and treatment interruptions because of toxicities. Moreover, in the intention-to-treat analysis, treatment responses were remarkably similar between the two treatment groups. This trial both suggests that a lower dose of imatinib is adequate for treatment if a response is seen and establishes 400 mg daily as the standard dose of imatinib for treating advanced GIST. A subsequent follow-up study 14 evaluated the feasibility, safety, and efficacy of crossing-over from low-dose to high-dose imatinib upon progression of disease. Of the patients possible for crossover, 55% (133 of 241 patients) crossed over. Although toxicities were often not high grade, slightly more than half of patients did not tolerate the dose escalation. Crossover resulted in a 33% increase in time to progression. Based on this post-hoc analysis, crossover to high-dose imatinib is feasible and safe in GIST patients who progress on low-dose therapy, and it also appears to delay disease progression, suggesting that there is therapeutic utility to an imatinib dose increase in patients with progression of disease. 4. Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group. Blay JY, Le Cesne A, Ray-Coquard I, et al. J Clin Oncol 2007 Mar 20;25(9):1107–13. 16 Hypothesis : Continuous imatinib improves PFS in patients with advanced GIST as compared with interrupted imatinib beyond 1 year of treatment. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 58 Interrupted imatinib n = 32 Continuous imatinib n = 26 None Improvement in PFS with continuous imatinib therapy versus interrupted imatinib therapy Median PFS 18 months (95% CI 15.0–23.6) versus 6.1 months (95% CI 3.5–9.7), P <.0001) Published abstract : PURPOSE: Imatinib is the standard treatment of advanced GISTs. It is not known whether imatinib may be stopped in patients in whom disease is controlled. METHODS: This prospective, randomized, multicentric phase 3 study was designed to compare continuous with interrupted imatinib beyond 1 year of treatment in patients with advanced GIST. The primary end point was PFS. Secondary end points included overall survival, response rate after reinitiation of imatinib, and quality of life. Early stopping rules in cases of rapid progression of disease were defined, with preplanned interim analyses. RESULTS: Between May 2002 and April 2004, 182 patients with advanced GIST were enrolled. Between May 2003 and April 2004, 98 patients in response or stable disease under imatinib reached more than 1 year of follow-up. Forty patients were not eligible for randomization, and 58 patients were randomly assigned, 32 and 26 patients in the interrupted and continuous arms, respectively. As of Oct. 15, 2005, 8 of 26 patients in the continuous group and 26 of 32 patients in the interrupted group had documented disease progression ( P <.0001). Twenty-four of 26 patients with documented progression in the interrupted arm responded to imatinib reintroduction. No differences in overall survival or imatinib resistance were observed between the two arms. Quality of life evaluated 6 months after random assignment using the 30-item quality of life questionnaire was not significantly different between the two groups of randomly assigned patients. CONCLUSION: Imatinib interruption results in rapid progression in most patients with advanced GIST, and cannot be recommended in routine practice unless patients experience significant toxicity. (Copyright [2007] American Society of Clinical Oncology, reprinted with permission.) Editor's summary and comments : This prospective, randomized, multicenter phase 3 trial was designed to determine whether imatinib therapy may be discontinued in patients whose disease is controlled following 1 year of treatment. The data suggested that therapy should be administered without interruption. During a 2-year period, 182 patients were enrolled. Following 1 year of treatment with imatinib, patients with metastatic or unresectable GIST who had either stable or partially responsive disease randomly were assigned either to continue or to discontinue imatinib therapy. Patients who were randomized to interrupted therapy were able to cross over to the treatment arm if they had progression of disease. Of this arm, 81% (26 of 32 patients) crossed over. Of these patients, 92% (24 of 26) responded to reintroduction of therapy. This suggested that even if there is no disease seen on a computed tomography (CT) scan, viable microscopic disease remains after imatinib therapy. Lending further validity to this concept, no patients in the continuous treatment arm had progression of disease at undetectable disease sites. Although there was no difference in overall survival, Imatinib resistance, or quality of life, continuous treatment resulted in a significantly longer PFS. This trial affirmed that imatinib therapy should not be sporadic and demonstrated that for patients wherein imatinib is discontinued, early progression is expected. 5. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomized controlled trial. Demetri GD, van Oosterom AT, Garrett CR, et al. Lancet 2006 Oct 14; 368(9544):1329–38. 17 Hypothesis : Sunitinib improves PFS in patients with unresectable GIST who have failed imatinib therapy compared with placebo. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 312 Sunitinib n = 207 Placebo n = 105 Based on prior outcome on imatinib treatment: progression within 6 months versus progression beyond 6 months or intolerance to imatinib Improvement in PFS Hazard ratio 0.33 (95% CI 0.23–0.47, P <.0001) Published abstract : BACKGROUND: No effective therapeutic options for patients with unresectable imatinib-resistant GIST are available. The authors did a randomized, double-blind, placebo-controlled, multicenter, international trial to assess tolerability and anticancer efficacy of sunitinib, a multitargeted tyrosine kinase inhibitor, in patients with advanced GIST who were resistant to or intolerant of previous treatment with imatinib. METHODS: Blinded sunitinib or placebo was given orally once daily at a 50-mg starting dose in 6-week cycles, with 4 weeks on and 2 weeks off treatment. The primary endpoint was time to tumor progression. Intention-to-treat, modified intention-to-treat, and per-protocol analyses were done. This study is registered at http://www.ClinicalTrials.gov , number NCT00075218. FINDINGS: Three hundred-twelve patients were randomized in a 2:1 ratio to receive sunitinib (n = 207) or placebo (n = 105); the trial was unblinded early when a planned interim analysis showed significantly longer time to tumor progression with sunitinib. Median time to tumor progression was 27.3 weeks (95% CI 16.0 to 32.1) in patients receiving sunitinib and 6.4 weeks (95% CI 4.4 to 10.0) in those on placebo (HR 0.33; P <.0001). Therapy was tolerated reasonably well; the most common treatment-related adverse events were fatigue, diarrhea, skin discoloration, and nausea. INTERPRETATION: The authors noted significant clinical benefit, including disease control and superior survival, with sunitinib compared with placebo in patients with advanced GIST after failure and discontinuation of imatinib. Tolerability was acceptable. (Copyright [2006] Elsevier.) Editor's summary and comments : In this international trial involving 56 centers, Demetri and colleagues validated the efficacy of sunitinib as a second-line therapy in advanced GIST. Patients who had failed imatinib therapy, either by disease progression or drug intolerance, were enrolled. Initially powered to detect a 50% improvement in median PFS, the study was unblinded early after a planned interim analysis. Using intention-to-treat analysis, PFS was superior in the sunitinib arm, extending the median time to progression by over 4 months. The threshold for difference in outcome was low, because sunitinib was being compared with placebo. Although not designed to evaluate overall survival, early data suggested an overall survival advantage in the sunitinib arm (HR of death 0.49, 95% CI 0.29 to 0.83). Given the limited options for patients who fail imatinib therapy, this study affirmed the viability of sunitinib as a second-line therapy. 6. Adjuvant imatinib mesylate after resection of localized, primary gastrointestinal stromal tumor: a randomized, double-blind, placebo-controlled trial. Dematteo RP, Ballman KV, Antonescu CR, et al. Lancet 2009 Mar 28;373(9669):1097–104. 18 Hypothesis : Imatinib 400 mg daily administered for 1 year after complete resection of localized, primary GIST improves recurrence-free survival over placebo. # Patients Randomized Study Groups Stratification Significance Demonstrated % Change Identified in Trial 713 Imatinib 400 mg daily n = 359 Placebo n = 354 By tumor size: ≥3–<6 cm, ≥6–<10 cm, or ≥10 cm Improvement in recurrence-free survival HR 0.35 (95% CI 0.22–0.53, P <.0001) Published abstract : BACKGROUND: GIST is the most common sarcoma of the intestinal tract. Imatinib mesylate is a small molecule that inhibits activation of the KIT and PDGFRα proteins, and is effective in first-line treatment of metastatic GIST. The authors postulated that adjuvant treatment with imatinib would improve recurrence-free survival compared with placebo after resection of localized, primary GIST. METHODS: The authors undertook a randomized phase 3, double-blind, placebo-controlled, multicenter trial. Eligible patients had complete gross resection of a primary GIST at least 3 cm in size and positive for the KIT protein by immunohistochemistry. Patients were randomly assigned, by a stratified biased coin design, to imatinib 400 mg (n = 359) or to placebo (n = 354) daily for 1 year after surgical resection. Patients and investigators were blinded to the treatment group. Patients assigned to placebo were eligible to cross over to imatinib treatment in the event of tumor recurrence. The primary endpoint was recurrence-free survival, and analysis was by intention to treat. Accrual was stopped early, because the trial results crossed the interim analysis efficacy boundary for recurrence-free survival. This study is registered with http://www.ClinicalTrials.gov , number NCT00041197. FINDINGS: All randomized patients were included in the analysis. At median follow-up of 19.7 months (range 0 to 56.4 months), 30 (8%) patients in the imatinib group and 70 (20%) in the placebo group had tumor recurrence or died. Imatinib significantly improved recurrence-free survival compared with placebo (98% [95% CI 96 to 100] versus 83% [95% CI 78 to 88] at 1 year; HR 0.35 [0.22 to 0.53]; one-sided P <.0001). Adjuvant imatinib was tolerated well, with the most common serious events being dermatitis (11 [3%] versus 0), abdominal pain (12 [3%] versus 6 [1%]), and diarrhea (10 [2%] versus 5 [1%]) in the imatinib group and hyperglycemia (two [<1%] versus seven [2%]) in the placebo group. INTERPRETATION: Adjuvant imatinib therapy is safe and seems to improve recurrence-free survival compared with placebo after the resection of primary GIST. FUNDING: Funding was provided by the US National Institutes of Health and Novartis Pharmaceuticals. (Copyright [2009] Elsevier.) ). Editor's summary and comments : While all other randomized controlled trials to date have explored the use of therapies in surgically incurable GIST, DeMatteo and colleagues evaluated the use of imatinib in an adjuvant setting, recognizing the significant risk of tumor recurrence following complete surgical resection. This trial originally was designed with overall survival as the primary end point, at a time when the efficacy of imatinib in advanced GIST had not yet been recognized fully. As the efficacy of imatinib became apparent, the study was redesigned to detect a 40% improvement in recurrence-free survival with a 90% power. The trial was closed early after interim analysis demonstrated efficacy in the therapy arm. With a median follow-up of nearly 20 months, a clear improvement in recurrence-free survival in the treatment arm was demonstrated. This effect was observed across all groups of the trial stratification. Differences in overall survival have not been demonstrated so far. In addition, the recurrence rate in the imatinib group was noted to increase appreciably around 18 months after surgery, raising the concern that 1 year of therapy may be inadequate for patients at high risk for recurrence. Although this study clearly demonstrates that empiric adjuvant imatinib reduces the rates of early recurrence, it is not yet clear whether this strategy improves overall survival over a strategy of watchful waiting. Furthermore, optimal patient selection criteria remain to be determined ( Fig. 2

PY - 2010/1

Y1 - 2010/1

N2 - Gastrointestinal (GI) stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract, constituting 80% of all GI mesenchymal tumors and approximately 20% of all small bowel malignancies, excluding lymphomas. This article provides a summary of recent randomized clinical trials of these tumors.

AB - Gastrointestinal (GI) stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract, constituting 80% of all GI mesenchymal tumors and approximately 20% of all small bowel malignancies, excluding lymphomas. This article provides a summary of recent randomized clinical trials of these tumors.

KW - Disease-free survival

KW - Gastrointestinal stromal tumor

KW - Recurrence-free survival

UR - http://www.scopus.com/inward/record.url?scp=70449380266&partnerID=8YFLogxK

U2 - 10.1016/j.soc.2009.09.004

DO - 10.1016/j.soc.2009.09.004

M3 - Review article

C2 - 19914562

AN - SCOPUS:70449380266

SN - 1055-3207

VL - 19

SP - 101

EP - 113

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

IS - 1

ER -

Randomized Clinical Trials in Gastrointestinal Stromal Tumors

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