Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir

Jomy M. George; Safia S. Kuriakose; Nicola Dee; Pam Stoll; Tahaniyat Lalani; Robin Dewar; Muhammad A. Khan; Muhammad T. Rehman; Zehava Grossman; Frank Maldarelli; Alice K. Pau

doi:10.1093/ofid/ofy221

Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir

Jomy M. George, Safia S. Kuriakose^*, Nicola Dee, Pam Stoll, Tahaniyat Lalani, Robin Dewar, Muhammad A. Khan, Muhammad T. Rehman, Zehava Grossman, Frank Maldarelli, Alice K. Pau

^*Corresponding author for this work

Infectious Disease Clinical Research Program (IDCRP)

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

Original language	English
Article number	ofy221
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofy221
State	Published - 1 Oct 2018

Keywords

T97A.
antiretroviral therapy
dolutegravir
drug resistance
salvage therapy

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10.1093/ofid/ofy221

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George, J. M., Kuriakose, S. S., Dee, N., Stoll, P., Lalani, T., Dewar, R., Khan, M. A., Rehman, M. T., Grossman, Z., Maldarelli, F., & Pau, A. K. (2018). Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir. Open Forum Infectious Diseases, 5(10), Article ofy221. https://doi.org/10.1093/ofid/ofy221

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title = "Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir",

abstract = "HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.",

keywords = "T97A., antiretroviral therapy, dolutegravir, drug resistance, salvage therapy",

author = "George, {Jomy M.} and Kuriakose, {Safia S.} and Nicola Dee and Pam Stoll and Tahaniyat Lalani and Robin Dewar and Khan, {Muhammad A.} and Rehman, {Muhammad T.} and Zehava Grossman and Frank Maldarelli and Pau, {Alice K.}",

note = "Publisher Copyright: {\textcopyright} Oxford University Press.",

year = "2018",

month = oct,

day = "1",

doi = "10.1093/ofid/ofy221",

language = "English",

volume = "5",

journal = "Open Forum Infectious Diseases",

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George, JM, Kuriakose, SS, Dee, N, Stoll, P, Lalani, T, Dewar, R, Khan, MA, Rehman, MT, Grossman, Z, Maldarelli, F & Pau, AK 2018, 'Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir', Open Forum Infectious Diseases, vol. 5, no. 10, ofy221. https://doi.org/10.1093/ofid/ofy221

Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir. / George, Jomy M.; Kuriakose, Safia S.; Dee, Nicola et al.
In: Open Forum Infectious Diseases, Vol. 5, No. 10, ofy221, 01.10.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir

AU - George, Jomy M.

AU - Kuriakose, Safia S.

AU - Dee, Nicola

AU - Stoll, Pam

AU - Lalani, Tahaniyat

AU - Dewar, Robin

AU - Khan, Muhammad A.

AU - Rehman, Muhammad T.

AU - Grossman, Zehava

AU - Maldarelli, Frank

AU - Pau, Alice K.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

AB - HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

KW - T97A.

KW - antiretroviral therapy

KW - dolutegravir

KW - drug resistance

KW - salvage therapy

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U2 - 10.1093/ofid/ofy221

DO - 10.1093/ofid/ofy221

M3 - Article

AN - SCOPUS:85054724397

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

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IS - 10

M1 - ofy221

ER -

Rapid Development of High-Level Resistance to Dolutegravir with Emergence of T97A Mutation in 2 Treatment-Experienced Individuals with Baseline Partial Sensitivity to Dolutegravir

Abstract

Keywords

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