TY - JOUR
T1 - Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig i acute HIV infection brief-communication
AU - The RV411 study group
AU - Colby, Donn J.
AU - Trautmann, Lydie
AU - Pinyakorn, Suteeraporn
AU - Leyre, Louise
AU - Pagliuzza, Amélie
AU - Kroon, Eugène
AU - Rolland, Morgane
AU - Takata, Hiroshi
AU - Buranapraditkun, Supranee
AU - Intasan, Jintana
AU - Chomchey, Nitiya
AU - Muir, Roshell
AU - Haddad, Elias K.
AU - Tovanabutra, Sodsai
AU - Ubolyam, Sasiwimol
AU - Bolton, Diane L.
AU - Fullmer, Brandie A.
AU - Gorelick, Robert J.
AU - Fox, Lawrence
AU - Crowell, Trevor A.
AU - Trichavaroj, Rapee
AU - O'Connell, Robert
AU - Chomont, Nicolas
AU - Kim, Jerome H.
AU - Michael, Nelson L.
AU - Robb, Merlin L.
AU - Phanuphak, Nittaya
AU - Ananworanich, Jintanat
AU - Phanuphak, P.
AU - Teeratakulpisarn, N.
AU - Chottanapund, S.
AU - De Souza, M.
AU - Fletcher, J.
AU - Tantivitayakul, P.
AU - Eamyoung, P.
AU - Sutthichom, D.
AU - Prueksakaew, P.
AU - Puttamaswin, S.
AU - Tipsuk, S.
AU - Benjapornpong, K.
AU - Ratnaratorn, N.
AU - Munkong, C.
AU - Tanjnareel, K.
AU - Kanaprach, R.
AU - Rerknimitr, R.
AU - Wattanaboonyongcharoen, P.
AU - Rojnuckarin, P.
AU - Manasnayakorn, S.
AU - Schuetz, A.
AU - Akapirat, S.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
AB - Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
UR - http://www.scopus.com/inward/record.url?scp=85048313622&partnerID=8YFLogxK
U2 - 10.1038/s41591-018-0026-6
DO - 10.1038/s41591-018-0026-6
M3 - Article
C2 - 29892063
AN - SCOPUS:85048313622
SN - 1078-8956
VL - 24
SP - 923
EP - 926
JO - Nature Medicine
JF - Nature Medicine
IS - 7
ER -