Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

B. A. Molitoris; A. C. Alfrey; P. S. Alfrey; N. L. Miller

doi:10.1038/ki.1988.150

Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

B. A. Molitoris, A. C. Alfrey, P. S. Alfrey, N. L. Miller

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Abstract

Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. Q(B) and Q(D) were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 ± 2.8 to 80.5 ± 7.6 ml/min (P < 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 ± 113 to 112 ± 12 min (P < 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 ± 191 to 1812 ± 720 μg/hr (P < 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 ± 36 vs. 93 ± 23, P < 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients.

Original language	English
Pages (from-to)	98-101
Number of pages	4
Journal	Kidney International
Volume	34
Issue number	1
DOIs	https://doi.org/10.1038/ki.1988.150
State	Published - 1988
Externally published	Yes

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@article{b466de4047c248119f74bddec4fb1fcf,

title = "Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers",

abstract = "Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. Q(B) and Q(D) were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 ± 2.8 to 80.5 ± 7.6 ml/min (P < 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 ± 113 to 112 ± 12 min (P < 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 ± 191 to 1812 ± 720 μg/hr (P < 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 ± 36 vs. 93 ± 23, P < 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients.",

author = "Molitoris, {B. A.} and Alfrey, {A. C.} and Alfrey, {P. S.} and Miller, {N. L.}",

note = "Funding Information: Acknowledgments We thank Linda M. Benson for her secretarial support. This work was supported by V.A. Research Funds, and B.A. Molitoris is a V.A.",

year = "1988",

doi = "10.1038/ki.1988.150",

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T1 - Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

AU - Molitoris, B. A.

AU - Alfrey, A. C.

AU - Alfrey, P. S.

AU - Miller, N. L.

N1 - Funding Information: Acknowledgments We thank Linda M. Benson for her secretarial support. This work was supported by V.A. Research Funds, and B.A. Molitoris is a V.A.

PY - 1988

Y1 - 1988

N2 - Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. Q(B) and Q(D) were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 ± 2.8 to 80.5 ± 7.6 ml/min (P < 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 ± 113 to 112 ± 12 min (P < 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 ± 191 to 1812 ± 720 μg/hr (P < 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 ± 36 vs. 93 ± 23, P < 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients.

AB - Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. Q(B) and Q(D) were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 ± 2.8 to 80.5 ± 7.6 ml/min (P < 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 ± 113 to 112 ± 12 min (P < 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 ± 191 to 1812 ± 720 μg/hr (P < 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 ± 36 vs. 93 ± 23, P < 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients.

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DO - 10.1038/ki.1988.150

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JO - Kidney International

JF - Kidney International

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ER -

Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

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