TY - JOUR
T1 - RecDraw
T2 - A software package for the representation of HIV-1 recombinant structures
AU - Kijak, Gustavo H.
AU - Tovanabutra, Sodsai
AU - Beyrer, Chris
AU - Sanders-Buell, Eric E.
AU - Arroyo, Miguel A.
AU - Robb, Merlin L.
AU - Michael, Nelson L.
AU - McCutchan, Francine E.
AU - Kim, Jerome H.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - The crucial role of recombination in HIV-1 biology is being increasingly recognized. In vitro studies have shown that up to 30 strand-transfer events may occur per viral replication cycle. Thus, recombination may surpass mutation as a major mechanism driving HIV-1 evolution. Currently, recombinant strains comprise 37% of the full-genome HIV-1 sequence database, including sequences representing 47 Circulating Recombinant Forms (CRFs) and more than 250 different Unique Recombinant Forms (URFs). Mapping of recombination breakpoints helps establish relationships among strains that are related by descent, such as CRF07-BC and CRF08-BC in China, and sheds light on their origin and epidemic spread. Additionally, unrelated recombinants sharing common breakpoints may reflect recombination hotspots within the viral genome. Here we present a software tool, RecDraw, for the graphical representation and efficient comparison of recombinant HIV-1 structures and breakpoints. RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6.
AB - The crucial role of recombination in HIV-1 biology is being increasingly recognized. In vitro studies have shown that up to 30 strand-transfer events may occur per viral replication cycle. Thus, recombination may surpass mutation as a major mechanism driving HIV-1 evolution. Currently, recombinant strains comprise 37% of the full-genome HIV-1 sequence database, including sequences representing 47 Circulating Recombinant Forms (CRFs) and more than 250 different Unique Recombinant Forms (URFs). Mapping of recombination breakpoints helps establish relationships among strains that are related by descent, such as CRF07-BC and CRF08-BC in China, and sheds light on their origin and epidemic spread. Additionally, unrelated recombinants sharing common breakpoints may reflect recombination hotspots within the viral genome. Here we present a software tool, RecDraw, for the graphical representation and efficient comparison of recombinant HIV-1 structures and breakpoints. RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6.
UR - http://www.scopus.com/inward/record.url?scp=78650272143&partnerID=8YFLogxK
U2 - 10.1089/aid.2010.0127
DO - 10.1089/aid.2010.0127
M3 - Article
C2 - 20961275
AN - SCOPUS:78650272143
SN - 0889-2229
VL - 26
SP - 1317
EP - 1321
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 12
ER -