Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

Robert L. Grossman; Jake Vinson; Elizabeth Bain; Karl Bisselou; Sanchi Chandan; Carolyn Compton; John Hu; Donald J. Johann; Frederick Jones; Gregory Jones; Suzanne LeBlang; Jerry S.H. Lee; Tara Lichtenberg; Christina M. Lockwood; John Lyle; Jean Francois Martini; Jason D. Merker; Lauren Saunders; Howard Scher; Stella Somiari; Jenny You; Lauren C. Leiman

doi:10.1111/cts.70227

Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

Robert L. Grossman, Jake Vinson, Elizabeth Bain, Karl Bisselou, Sanchi Chandan, Carolyn Compton, John Hu, Donald J. Johann, Frederick Jones, Gregory Jones, Suzanne LeBlang, Jerry S.H. Lee, Tara Lichtenberg, Christina M. Lockwood, John Lyle, Jean Francois Martini, Jason D. Merker, Lauren Saunders, Howard Scher, Stella SomiariJenny You, Lauren C. Leiman^*

^*Corresponding author for this work

Surgery

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Abstract

In 2020, BLOODPAC recommended 11 pre-analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases. This article expands on that work by recommending 22 clinical context and 10 patient context data elements. These elements, essential for liquid biopsy data submitted to repositories like the BLOODPAC Data Commons, cover tumor characteristics, disease progression, and patient demographics, supporting biomarker validation, research, and clinical trials.

Original language	English
Article number	e70227
Journal	Clinical and Translational Science
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/cts.70227
State	Published - Apr 2025

Keywords

clinical context data elements
data commons
liquid biopsy
patient context data elements

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10.1111/cts.70227

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Grossman, R. L., Vinson, J., Bain, E., Bisselou, K., Chandan, S., Compton, C., Hu, J., Johann, D. J., Jones, F., Jones, G., LeBlang, S., Lee, J. S. H., Lichtenberg, T., Lockwood, C. M., Lyle, J., Martini, J. F., Merker, J. D., Saunders, L., Scher, H., ... Leiman, L. C. (2025). Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons. Clinical and Translational Science, 18(4), Article e70227. https://doi.org/10.1111/cts.70227

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title = "Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons",

abstract = "In 2020, BLOODPAC recommended 11 pre-analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases. This article expands on that work by recommending 22 clinical context and 10 patient context data elements. These elements, essential for liquid biopsy data submitted to repositories like the BLOODPAC Data Commons, cover tumor characteristics, disease progression, and patient demographics, supporting biomarker validation, research, and clinical trials.",

keywords = "clinical context data elements, data commons, liquid biopsy, patient context data elements",

author = "Grossman, \{Robert L.\} and Jake Vinson and Elizabeth Bain and Karl Bisselou and Sanchi Chandan and Carolyn Compton and John Hu and Johann, \{Donald J.\} and Frederick Jones and Gregory Jones and Suzanne LeBlang and Lee, \{Jerry S.H.\} and Tara Lichtenberg and Lockwood, \{Christina M.\} and John Lyle and Martini, \{Jean Francois\} and Merker, \{Jason D.\} and Lauren Saunders and Howard Scher and Stella Somiari and Jenny You and Leiman, \{Lauren C.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.",

year = "2025",

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doi = "10.1111/cts.70227",

language = "English",

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Grossman, RL, Vinson, J, Bain, E, Bisselou, K, Chandan, S, Compton, C, Hu, J, Johann, DJ, Jones, F, Jones, G, LeBlang, S, Lee, JSH, Lichtenberg, T, Lockwood, CM, Lyle, J, Martini, JF, Merker, JD, Saunders, L, Scher, H, Somiari, S, You, J & Leiman, LC 2025, 'Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons', Clinical and Translational Science, vol. 18, no. 4, e70227. https://doi.org/10.1111/cts.70227

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T1 - Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

AU - Grossman, Robert L.

AU - Vinson, Jake

AU - Bain, Elizabeth

AU - Bisselou, Karl

AU - Chandan, Sanchi

AU - Compton, Carolyn

AU - Hu, John

AU - Johann, Donald J.

AU - Jones, Frederick

AU - Jones, Gregory

AU - LeBlang, Suzanne

AU - Lee, Jerry S.H.

AU - Lichtenberg, Tara

AU - Lockwood, Christina M.

AU - Lyle, John

AU - Martini, Jean Francois

AU - Merker, Jason D.

AU - Saunders, Lauren

AU - Scher, Howard

AU - Somiari, Stella

AU - You, Jenny

AU - Leiman, Lauren C.

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AB - In 2020, BLOODPAC recommended 11 pre-analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases. This article expands on that work by recommending 22 clinical context and 10 patient context data elements. These elements, essential for liquid biopsy data submitted to repositories like the BLOODPAC Data Commons, cover tumor characteristics, disease progression, and patient demographics, supporting biomarker validation, research, and clinical trials.

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KW - data commons

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M1 - e70227

ER -

Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

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Keywords

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