Refractory Malignant Eosinophilic Colitis Leading to Ischemic Colitis

Christina Awad; Benjamin Bailes; Christian Horn; Anish Patel

doi:10.14309/crj.0000000000000991

Refractory Malignant Eosinophilic Colitis Leading to Ischemic Colitis

Christina Awad, Benjamin Bailes, Christian Horn, Anish Patel

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Eosinophilic colitis (EC) is the most uncommon disease within the spectrum of eosinophilic gastrointestinal disorders. Currently, there are no well-established diagnostic criteria and no approved Food and Drug Administration therapies. We discuss a case of a 30-year-old man with refractory malignant EC leading to ischemic colitis. The patient was tried on multiple therapies, including a combination therapy of benralizumab and vedolizumab, which were unsuccessful. Unfortunately, the patient ultimately required a total proctocolectomy. More studies need to be performed to treat patients with severe refractory cases of EC.

Original language	American English
Pages (from-to)	e00991
Journal	ACG case reports journal
Volume	10
Issue number	2
DOIs	https://doi.org/10.14309/crj.0000000000000991
State	Published - Feb 2023

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10.14309/crj.0000000000000991

Cite this

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title = "Refractory Malignant Eosinophilic Colitis Leading to Ischemic Colitis",

abstract = "Eosinophilic colitis (EC) is the most uncommon disease within the spectrum of eosinophilic gastrointestinal disorders. Currently, there are no well-established diagnostic criteria and no approved Food and Drug Administration therapies. We discuss a case of a 30-year-old man with refractory malignant EC leading to ischemic colitis. The patient was tried on multiple therapies, including a combination therapy of benralizumab and vedolizumab, which were unsuccessful. Unfortunately, the patient ultimately required a total proctocolectomy. More studies need to be performed to treat patients with severe refractory cases of EC.",

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AB - Eosinophilic colitis (EC) is the most uncommon disease within the spectrum of eosinophilic gastrointestinal disorders. Currently, there are no well-established diagnostic criteria and no approved Food and Drug Administration therapies. We discuss a case of a 30-year-old man with refractory malignant EC leading to ischemic colitis. The patient was tried on multiple therapies, including a combination therapy of benralizumab and vedolizumab, which were unsuccessful. Unfortunately, the patient ultimately required a total proctocolectomy. More studies need to be performed to treat patients with severe refractory cases of EC.

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