Refractory Pseudomonas bacteremia in a 2-year-old sterilized by bacteriophage therapy

C. Duplessis; B. Biswas; B. Hanisch; M. Perkins; M. Henry; J. Quinones; D. Wolfe; L. Estrella; T. Hamilton

doi:10.1093/jpids/pix056

Refractory Pseudomonas bacteremia in a 2-year-old sterilized by bacteriophage therapy

C. Duplessis^*, B. Biswas, B. Hanisch, M. Perkins, M. Henry, J. Quinones, D. Wolfe, L. Estrella, T. Hamilton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

Original language	English
Pages (from-to)	253-256
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	7
Issue number	3
DOIs	https://doi.org/10.1093/jpids/pix056
State	Published - 17 Aug 2018
Externally published	Yes

Keywords

Bacteremia
Bacteriophage
Multidrug resistance
Pseudomonas aeruginosa
Sepsis

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10.1093/jpids/pix056

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abstract = "Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.",

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author = "C. Duplessis and B. Biswas and B. Hanisch and M. Perkins and M. Henry and J. Quinones and D. Wolfe and L. Estrella and T. Hamilton",

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AU - Duplessis, C.

AU - Biswas, B.

AU - Hanisch, B.

AU - Perkins, M.

AU - Henry, M.

AU - Quinones, J.

AU - Wolfe, D.

AU - Estrella, L.

AU - Hamilton, T.

PY - 2018/8/17

Y1 - 2018/8/17

N2 - Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

AB - Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

KW - Bacteremia

KW - Bacteriophage

KW - Multidrug resistance

KW - Pseudomonas aeruginosa

KW - Sepsis

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ER -

Refractory Pseudomonas bacteremia in a 2-year-old sterilized by bacteriophage therapy

Abstract

Keywords

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