Refrigerated platelets for the treatment of acute bleeding: A review of the literature and reexamination of current standards

Heather F. Pidcoke, Philip C. Spinella, Anand K. Ramasubramanian, Geir Strandenes, Tor Hervig, Paul M. Ness, Andrew P. Cap*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


This review is a synopsis of the decisions that shaped global policy on platelet (PLT) storage temperature and a focused appraisal of the literature on which those discussions were based. We hypothesize that choices were centered on optimization of preventive PLT transfusion strategies, possibly to the detriment of the therapeutic needs of acutely bleeding patients. Refrigerated PLTs are a better hemostatic product, and they are safer in that they are less prone to bacterial contamination. They were abandoned during the 1970s because of the belief that clinically effective PLTs should both be hemostatically functional and survive in circulation for several days as indicated for prophylactic transfusion; however, clinical practice may be changing. Data from two randomized controlled trials bring into question the concept that stable autologous stem cell transplant patients with hypoproliferative thrombocytopenia should continue to receive prophylactic transfusions. At the same time, new findings regarding the efficacy of cold PLTs and their potential role in treating acute bleeding have revived the debate regarding optimal PLT storage temperature. In summary, a "one-size-fits-all" strategy for PLT storage may not be adequate, and a reexamination of whether cold-stored PLTs should be offered as a widely available therapeutic product may be indicated.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
Issue numberSUPPL. 1
StatePublished - May 2014
Externally publishedYes


  • Cold platelets
  • acute hemorrhage
  • damage control resuscitation
  • hypoproliferative thrombocytopenia
  • massive transfusion protocols
  • platelet storage temperature
  • severe hemorrhage
  • trauma


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