Regenerative Medicine Strategies for Esophageal Repair

Ricardo Londono, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Pathologies that involve the structure and/or function of the esophagus can be life-threatening. The esophagus is a complex organ comprising nonredundant tissue that does not have the ability to regenerate. Currently available interventions for esophageal pathology have limited success and are typically associated with significant morbidity. Hence, there is currently an unmet clinical need for effective methods of esophageal repair. The present article presents a review of esophageal disease along with the anatomic and functional consequences of each pathologic process, the shortcomings associated with currently available therapies, and the latest advancements in the field of regenerative medicine with respect to strategies for esophageal repair from benchtop to bedside.

Original languageEnglish
Pages (from-to)393-410
Number of pages18
JournalTissue Engineering - Part B: Reviews
Volume21
Issue number4
DOIs
StatePublished - 1 Aug 2015
Externally publishedYes

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