Regional distribution of arylamine and arylalkylamine N-acetyltransferase activities in the rat brain

S. Gaudet; M. Palkovits; M. A.A. Namboodiri

doi:10.1016/0006-8993(91)91645-H

Regional distribution of arylamine and arylalkylamine N-acetyltransferase activities in the rat brain

S. Gaudet, M. Palkovits, M. A.A. Namboodiri^*

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Arylamine and arylalkylamine N-acetyltransferase (NAT) activities were measured separately in different areas of the rat brain using specific substrates. Relatively high levels of arylamine NAT activity were detected in all areas examined. Arylalkylamine NAT activity in these areas ranged from 2 to 5% of the arylamine NAT activity. The possibility that arylamine NAT may be involved in the control of kynurenine metabolism in the brain is discussed.

Original language	English
Pages (from-to)	355-357
Number of pages	3
Journal	Brain Research
Volume	539
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)91645-H
State	Published - 25 Jan 1991

Keywords

Detoxification
Extrapineal melatonin synthesis
Kynurenine
Neurotoxicity
Quinolinic acid

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10.1016/0006-8993(91)91645-H

Cite this

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abstract = "Arylamine and arylalkylamine N-acetyltransferase (NAT) activities were measured separately in different areas of the rat brain using specific substrates. Relatively high levels of arylamine NAT activity were detected in all areas examined. Arylalkylamine NAT activity in these areas ranged from 2 to 5% of the arylamine NAT activity. The possibility that arylamine NAT may be involved in the control of kynurenine metabolism in the brain is discussed.",

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KW - Quinolinic acid

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