Abstract
Store-operate Ca 2+ channels gate Ca 2+ entry into the cytoplasm in response to the depletion of Ca 2+ from endoplasmic reticulum Ca 2+ stores. The major molecular components of store-operated Ca 2+ entry are STIM (stromal-interacting molecule) 1 (and in some instances STIM2) that serves as the endoplasmic reticulum Ca 2+ sensor, and Orai (Orai1, Orai2 and Orai3) which function as pore-forming subunits of the store-operated channel. It has been known for some time that store-operated Ca 2+ entry is shut down during cell division. Recent work has revealed complex mechanisms regulating the functions and locations of both STIM1 and Orai1 in dividing cells.
| Original language | English |
|---|---|
| Pages (from-to) | 119-123 |
| Number of pages | 5 |
| Journal | Biochemical Society Transactions |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2012 |
Keywords
- Calcium entry
- Cell division
- Orai
- Protein phosphorylation
- Store-operated channel
- Stromal-interacting molecule protein (STIM protein)
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