Relation of QT c duration heterogeneity to mortality following orthotopic heart transplantation

Mark W. Kolasa; Joseph C. Lee; J. Edwin Atwood; Rachel R. Marcus; Robert E. Eckart

doi:10.1016/j.amjcard.2004.09.053

Relation of QT _c duration heterogeneity to mortality following orthotopic heart transplantation

Mark W. Kolasa^*, Joseph C. Lee, J. Edwin Atwood, Rachel R. Marcus, Robert E. Eckart

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Studies of heart failure patients have demonstrated that serial QT prolongation and abnormally prolonged QT intervals are associated with greater mortality. Serial QT interval measurements in patients who undergo orthotopic heart transplantation (OHT) may quantify the degree of myocardial repolarization heterogeneity and serve as a marker of arrhythmogenic substrate. In this study, the mean survival for those with "stable" QT _c intervals (a change of -10 to 10 ms/year) was 124 ± 8 months versus 63 ± 25 months in those with annual QT _c changes of >10 ms (p = 0.009). Ventricular repolarization heterogeneity may serve as a marker of identifying high-risk patients after OHT.

Original language	English
Pages (from-to)	431-432
Number of pages	2
Journal	The American Journal of Cardiology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1016/j.amjcard.2004.09.053
State	Published - 1 Feb 2005
Externally published	Yes

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title = "Relation of QT c duration heterogeneity to mortality following orthotopic heart transplantation",

abstract = "Studies of heart failure patients have demonstrated that serial QT prolongation and abnormally prolonged QT intervals are associated with greater mortality. Serial QT interval measurements in patients who undergo orthotopic heart transplantation (OHT) may quantify the degree of myocardial repolarization heterogeneity and serve as a marker of arrhythmogenic substrate. In this study, the mean survival for those with {"}stable{"} QT c intervals (a change of -10 to 10 ms/year) was 124 ± 8 months versus 63 ± 25 months in those with annual QT c changes of >10 ms (p = 0.009). Ventricular repolarization heterogeneity may serve as a marker of identifying high-risk patients after OHT.",

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AU - Kolasa, Mark W.

AU - Lee, Joseph C.

AU - Atwood, J. Edwin

AU - Marcus, Rachel R.

AU - Eckart, Robert E.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Studies of heart failure patients have demonstrated that serial QT prolongation and abnormally prolonged QT intervals are associated with greater mortality. Serial QT interval measurements in patients who undergo orthotopic heart transplantation (OHT) may quantify the degree of myocardial repolarization heterogeneity and serve as a marker of arrhythmogenic substrate. In this study, the mean survival for those with "stable" QT c intervals (a change of -10 to 10 ms/year) was 124 ± 8 months versus 63 ± 25 months in those with annual QT c changes of >10 ms (p = 0.009). Ventricular repolarization heterogeneity may serve as a marker of identifying high-risk patients after OHT.

AB - Studies of heart failure patients have demonstrated that serial QT prolongation and abnormally prolonged QT intervals are associated with greater mortality. Serial QT interval measurements in patients who undergo orthotopic heart transplantation (OHT) may quantify the degree of myocardial repolarization heterogeneity and serve as a marker of arrhythmogenic substrate. In this study, the mean survival for those with "stable" QT c intervals (a change of -10 to 10 ms/year) was 124 ± 8 months versus 63 ± 25 months in those with annual QT c changes of >10 ms (p = 0.009). Ventricular repolarization heterogeneity may serve as a marker of identifying high-risk patients after OHT.

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JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

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ER -

Relation of QT c duration heterogeneity to mortality following orthotopic heart transplantation

Abstract

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Relation of QT _c duration heterogeneity to mortality following orthotopic heart transplantation