TY - JOUR
T1 - Relationship between orientation to a blast and pressure wave propagation inside the rat brain
AU - Chavko, Mikulas
AU - Watanabe, Tomas
AU - Adeeb, Saleena
AU - Lankasky, Jason
AU - Ahlers, Stephen T.
AU - McCarron, Richard M.
N1 - Funding Information:
This work was supported by CDMRP Work Unit #2780.00000.22.A0810. The experiments reported herein were conducted according to the principles set forth in the “Guide for the Care and Use of Laboratory Animals”, Institute of Laboratory Animal Resources, National Research Council, National Academy Press, 1996 and was approved by WRAIR/NMRC IACUC Committee. The opinions expressed in this presentation are those of the authors and do not reflect the official policy of the Department of Navy, Department of Defense, of the U.S. Government.
PY - 2011/1/30
Y1 - 2011/1/30
N2 - Exposure to a blast wave generated during an explosion may result in brain damage and related neurological impairments. Several mechanisms by which the primary blast wave can damage the brain have been proposed, including: (1) a direct effect of the shock wave on the brain causing tissue damage by skull flexure and propagation of stress and shear forces; and (2) an indirect transfer of kinetic energy from the blast, through large blood vessels and cerebrospinal fluid (CSF), to the central nervous system. To address a basic question related to the mechanisms of blast brain injury, pressure was measured inside the brains of rats exposed to a low level of blast (~35. kPa), while positioned in three different orientations with respect to the primary blast wave; head facing blast, right side exposed to blast and head facing away from blast. Data show different patterns and durations of the pressure traces inside the brain, depending on the rat orientation to blast. Frontal exposures (head facing blast) resulted in pressure traces of higher amplitude and longer duration, suggesting direct transmission and reflection of the pressure inside the brain (dynamic pressure transfer). The pattern of the pressure wave inside the brain in the head facing away from blast exposures assumes contribution of the static pressure, similar to hydrodynamic pressure to the pressure wave inside the brain.
AB - Exposure to a blast wave generated during an explosion may result in brain damage and related neurological impairments. Several mechanisms by which the primary blast wave can damage the brain have been proposed, including: (1) a direct effect of the shock wave on the brain causing tissue damage by skull flexure and propagation of stress and shear forces; and (2) an indirect transfer of kinetic energy from the blast, through large blood vessels and cerebrospinal fluid (CSF), to the central nervous system. To address a basic question related to the mechanisms of blast brain injury, pressure was measured inside the brains of rats exposed to a low level of blast (~35. kPa), while positioned in three different orientations with respect to the primary blast wave; head facing blast, right side exposed to blast and head facing away from blast. Data show different patterns and durations of the pressure traces inside the brain, depending on the rat orientation to blast. Frontal exposures (head facing blast) resulted in pressure traces of higher amplitude and longer duration, suggesting direct transmission and reflection of the pressure inside the brain (dynamic pressure transfer). The pattern of the pressure wave inside the brain in the head facing away from blast exposures assumes contribution of the static pressure, similar to hydrodynamic pressure to the pressure wave inside the brain.
KW - Blast overpressure
KW - Explosion
KW - Rat brain
KW - Transmission
UR - http://www.scopus.com/inward/record.url?scp=78650955636&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2010.11.019
DO - 10.1016/j.jneumeth.2010.11.019
M3 - Article
C2 - 21129403
AN - SCOPUS:78650955636
SN - 0165-0270
VL - 195
SP - 61
EP - 66
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 1
ER -