Renal biopsy donor group: The influence of glomerulosclerosis on transplant outcomes

J. Cicciarelli*, Y. Cho, R. Mateo, M. El-Shahawy, Y. Iwaki, R. Selby

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.

Original languageEnglish
Pages (from-to)712-713
Number of pages2
JournalTransplantation Proceedings
Issue number2
StatePublished - Mar 2005
Externally publishedYes


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