TY - JOUR
T1 - Renal biopsy donor group
T2 - The influence of glomerulosclerosis on transplant outcomes
AU - Cicciarelli, J.
AU - Cho, Y.
AU - Mateo, R.
AU - El-Shahawy, M.
AU - Iwaki, Y.
AU - Selby, R.
PY - 2005/3
Y1 - 2005/3
N2 - The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.
AB - The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.
UR - http://www.scopus.com/inward/record.url?scp=17844406632&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2004.12.108
DO - 10.1016/j.transproceed.2004.12.108
M3 - Article
C2 - 15848510
AN - SCOPUS:17844406632
SN - 0041-1345
VL - 37
SP - 712
EP - 713
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 2
ER -