Renal biopsy donor group: The influence of glomerulosclerosis on transplant outcomes

J. Cicciarelli; Y. Cho; R. Mateo; M. El-Shahawy; Y. Iwaki; R. Selby

doi:10.1016/j.transproceed.2004.12.108

Renal biopsy donor group: The influence of glomerulosclerosis on transplant outcomes

J. Cicciarelli^*
, Y. Cho
, R. Mateo
, M. El-Shahawy
, Y. Iwaki
, R. Selby

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.

Original language	English
Pages (from-to)	712-713
Number of pages	2
Journal	Transplantation Proceedings
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.transproceed.2004.12.108
State	Published - Mar 2005
Externally published	Yes

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title = "Renal biopsy donor group: The influence of glomerulosclerosis on transplant outcomes",

abstract = "The UNOS donor population was examined from 1999 to 2002, and approximately 25\% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10\% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10\% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.",

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T2 - The influence of glomerulosclerosis on transplant outcomes

AU - Cicciarelli, J.

AU - Cho, Y.

AU - Mateo, R.

AU - El-Shahawy, M.

AU - Iwaki, Y.

AU - Selby, R.

PY - 2005/3

Y1 - 2005/3

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AB - The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P <. 001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P <. 001) to graft survival, delayed graft function, and primary nonfunction. Cox regression showed significant relative risk (RR) for >10% GS, hypertension, donors over the age of 50, and African American recipients. RR in donors with >10% GS could be ameliorated (P <. 001) by choosing donors with <5 HLA-A, -B, or -DR mismatches (MM), or recipients who were nonsensitized, and/or first transplant. Risk should be managed in donors by choosing appropriate recipients and high-risk immunosuppresion protocols.

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Renal biopsy donor group: The influence of glomerulosclerosis on transplant outcomes

Abstract

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