Resorbable bioscaffold for esophageal repair in a dog model

Stephen Badylak*, Staffan Meurling, Mike Chen, Alan Spievack, Abby Simmons-Byrd

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

272 Scopus citations

Abstract

Purpose: Porcine-derived, xenogeneic extracellular matrix (ECM) derived from either the small intestinal submucosa (SIS) or urinary bladder submucosa (UBS) was used as a tissue scaffold for esophageal repair in a dog model. Methods: Patch defects measuring approximately 5 cm in length and encompassing 40% to 50% of the circumference of the esophagus or complete circumferential segmental defects measuring 5 cm in length were created by surgical resection in healthy adult female dogs. The defects were repaired with ECM scaffolds derived from either SIS or UBS. The animals were kept alive for periods ranging from 4 days to 15 months. Results: The xenogeneic scaffolds used for repair of the patch defects were resorbed completely within 30 to 60 days and showed replacement by skeletal muscle, which was oriented appropriately and contiguous with adjacent normal esophageal skeletal muscle, organized collagenous connective tissue, and a complete and intact squamous epithelium. No signs of clinical esophageal dysfunction were seen in any of the animals with the patch defect repair. The xenogeneic scaffolds configured into tubes for repair of the segmental defects all showed stricture within 45 days of surgery. Conclusion: These ECMs show promise as a treatment option for esophageal repair, but stricture remains problematic for complete tube grafts. Copyright (C) 2000 W.B. Saunders Company.

Original languageEnglish
Pages (from-to)1097-1103
Number of pages7
JournalJournal of Pediatric Surgery
Volume35
Issue number7
DOIs
StatePublished - Jul 2000
Externally publishedYes

Keywords

  • Esophagus
  • Extracellular matrix
  • Small intestinal submucosa
  • Tissue engineering
  • Urinary bladder submucosa

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