Retrospective serosurvey of leptospirosis among patients with acute febrile illness and hepatitis in Egypt

Tharwat F. Ismail, Momtaz O. Wasfy, Bassem Abdul-Rahman, Clinton K. Murray, Duane R. Hospenthal, Moustafa Abdel-Fadeel, Mohamed Abdel-Maksoud, Ahmed Samir, Mahmoud E. Hatem, John Klena, Guillermo Pimentel, Nasr El-Sayed, Rana Hajjeh

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The epidemiologic status of leptospirosis in Egypt has not been well defined because of difficulties in disease diagnosis. A retrospective study was conducted to detect leptospiral antibodies among undiagnosed acute febrile illness (AFI) and hepatitis cases. Approximately 16% of both AFI (141/886) and acute hepatitis (63/392) cases showed seroreactivity to Leptospira IgM by ELISA and microscopic agglutination test (MAT). Canicola, Djasiman, Grippotyphosa, Pyrogenes, Icterohemorrhagiae, and Pomona were the most commonly reactive serovars among patients with AFI. Djasiman, Grippotyphosa and Icterohemorrhagiae were the most reactive among patients with acute hepatitis. This study represents the first systematic report of Leptospira associated with patients with AFI and hepatitis in Egypt. Physicians need to have increased awareness about the importance of leptospirosis in the differential diagnosis of AFI and acute hepatitis in Egypt. In addition, laboratory capacity should be developed at fever hospitals to diagnose leptospirosis.

Original languageEnglish
Pages (from-to)1085-1089
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number6
StatePublished - Dec 2006
Externally publishedYes


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